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18 Cards in this Set
- Front
- Back
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What is sulfasalazine?
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A combination of a sulfapyridine (antibacterial) and 5-ASA(anti-inflammatory) that is activated by colinic bacteria
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What is Infiximab?
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A monoclonal Antibody to TNF-Alpha a proinflammatory cytokine.
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What does the colon bacteria break apart?
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The AZO bond (N-N)
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When would you use sulfasalazine?
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Mild to moderate Crohn's and Ulcerative colitis
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When would one use Glucocorticoids + sulfasalazine?
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Severe Crohn's and Ulcerative Colitis
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Rash, fever, Steven-Johnson syndrome, hepatitis, pneumonitis, hemolytic anemia, bone marrow suppression
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Sulfasalazine
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Inhibits intestinal folate absorption
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sulfasalazine
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__% of a sulfasalazine dose cleaved by colonic bacteria
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70
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Inhibit production of inflammatory factors TNF-, IL-1, IL-8
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Glucocorticoids
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__% of IBD patients fail to respond adequately to glucocorticoids
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45-60%
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Delayed release cortico steroid?
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Budensonide
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The most common glucocorticoid used?
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prednisone
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Promotes:
complement activation, antibody-mediated apoptosis, cellular cytotoxicity |
Inflixamab
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CONTRAINDICATED in severe congestive heart failure
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Inflixamab
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Delayed serum sickness-like reaction
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Inflixamab
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Frank lupus-like syndrome rarely
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Inflixamab
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Some data suggest that some bacterial strains may be anti-inflammatory and others may be pro-inflammatory. What are the bacteria's being tested now?
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Lactobacillus and Saccaromyces Bacteroides
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Fistula Tx - Crohn’s
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Azathioprine
6-Mercaptopurine |
