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24 Cards in this Set
- Front
- Back
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H2 blockers..
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cimetidine, rantidine, famotidine, nizatidine (table for "2" to DINE)
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MOA of H2 blockers and use...
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block H secretion from parietal cells. Used for peptic ulcers, gastritis, mild eso reflux
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Toxicity of H2 blockers...
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cimetidine- p450 inhibitor w/ antiandrogenic effects: prolactin release, gynecomastia, decr libido. Cimetidine can cross BBB and placenta. Cimetidine and rantidine decr Creatinine excretion.
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PPIs...
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omeprazole, lansoprazole
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MOA of PPIs...
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irreversibly inhibit H/K ATPase on paretial cells
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use of PPIs...
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peptic ulcer, gastritis, eso reflux (all like H2 blockers). Zollinger-Ellison syndrome
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Bismuth and sucralfate MOA... use...
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bind to ulcer base to provide physical barrier and allow bicarb secretion. Used for ulcer healing and travelers diarrhea
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Misoprostol MOA...
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PGE1 analog that incr mucous barrier and decr acid prodxn.
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use of misoprostol...
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prevent NSAId-induced ulcers, maintain PDA, induce labor
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toxicity of misoprostol...
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diarrhea. Avoid if woman of childbearing age (Miss yo' prognancy is started)
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Muscarinic antagonists used in peptic ulcer dx...
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pirenzepine, propantheline
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MOA of pirenzepine and propantheline...
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block M1 receptors on ECL cells to decr his secrtiona dn M3's on parietal cells to decr acid secretion
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toxicity of musc antagonists pirenzepine, propantheline...
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tachycardia, dry mouth, poor lens accomodation
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overuse of Al hydroxide causes...
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constipation, hypophosph, proximal muscle weakness, osteodystrophy, seizures
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overuse of Mg hydroxide..
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diarrhea, hyporeflexia, hypotension, cardiac arrest
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overuse of Ca carbonate...
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hyperCa, rebound acid incr. can chelate and decr effectiveness of tetracycline and other drugs
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infliximab MOA and use...
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monoclonal ab to TNF. used for Crohn's and RA.
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toxicity of infliximab...
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resp infxn (reactivated TB), fever, hypotension
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Sulfasalazine MOA and use...
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sulfapyridine antibacterial + aminosaliclic acid anti inflamatory. Activated by colonic bacteria. used for UC and Crohn's
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toxicity of sulfasalazine..
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malaise, nausea, sulfa toxicity, oligospermia
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onansetron MOA and use...
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seratonin antag. central acting antiemetic used to control post-op vomitting. can give HA and constipation
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MOA of metoclopramide...
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D2 receptor antagonist. incr resting tone, contractivity, LES tone, motility.
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use of metoclopramide...
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diabetic and post-op gastroparesis
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toxicity of metoclopramide...
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Parkinson effects. restlessness, drowsiness, fatigue, depression, N/D. interacts w/ digoxin and diabetic agents. Don't use in patient w/ small bowel obstrxn
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