Gi Pharm

Front 1

H2 Blockers

1)Names
2)MOA
3)Use
4)Toxicity

Back 1

1)Cimetidine, Rinitidine, Nizatidine

2) Reversible block of Histamine receptors, causing decreased secretion of HCl from Parietal cell (blocks synergistic effect)

3)Peptic Ulcers, Gastritis, esophageal reflux

4) Cimetidine inhibits p450, antiadrogenic effect, and BLOCKS CREATININE seretion

Front 2

Proton Pump Inhibitors
1)Names
2)MOA
3)Uses
4)Side Effect

Back 2

1)Omeprazole, Lansoprazole
2)Irreversibly inhibit H+/K+ pump in parietal cells

3)Peptic ulcers, gastritis, Reflux, Zollinger-Ellison syndrome (excess gastrin)

4)decreases Phenytoin excretion

Front 3

Bismuth, Sucralfate
1)MOA
2)Use
3)Toxicity

Back 3

1)Binds ulcer base to provide protection, and allows HCO3- to reestablish pH gradient

2)Ulcer healing, and part of triple therapy, Diarrhea

3)Prevents absorption of Quinilones and Tetracyclines

Front 4

Triple Therapy

Back 4

Metronidazole, Bismuth, Amoxicillin (Tetracycline)

Front 5

Misoprostol
1)MOA
2)Use
3)Toxicity

Back 5

1)PGE1 analog to increase secretion of HCO3- and decrease acid secretion

2)Prevents NSAID induced ulcers, keeps patent ductus arteriosis open, and can induce labor

3)Diarrhea, causes abortion

Front 6

HMG CoA Reductase (Statins)
1)MOA
2)Effect on LDL, HDL, TAGs
3)Side Effects

Back 6

1) Prevents synthesis of new cholesterol in the liver by blocking HMG-CoA Reductase (rate limiting step)

2)Drops LDL the most, slight increase in HDL, minor decrease in TAG

3)Expensive, reversible increase in LFTs, myositis

Front 7

Niacin
1)MOA
2)Effect on LDL, HDL, TAGs
3)Side Effects

Back 7

1)Prevents release of formed VLDLs from liver

2)decreases LDL, increases HDL, minor decrease in TAG

3) Red, flushed face (prevented by aspirin)

Front 8

Bile Acid Resins
1)MOA
2)Effect on LDL, HDL, and TAG
3)Toxicity

Back 8

1) Binds bile acids in the intestines and causes them to be excreted. This causes de nova synthesis from endogenous cholesterol to deplete stores

2) Lowers LDL significantly, no effect on HDL, and slightly increases TAGs

3) Tastes bad and causes diarrhea

Front 9

Cholesterol Blockers- Ezetimibe

1)MOA
2)Effects on LDL, HDL, and TAGs
3)Toxicity

Back 9

1)Prevents absorption of dietery cholesterol
2) lowers LDL only
3)Rare increase in LFTs

Front 10

Fibrates (gefimbrozil, clofibrate, fenofibrate)
1)MOA
2)LDL,HDL,TAGs
3)Toxicity

Back 10

1)Blocks Lipoprotein Lipase in the periphery
2)Lowers LDL, increase HDL, massive decrease in TAG
3)Myositis, and increased LFTs

Front 11

Muscarinic Blockers (Pirenzepine, propantheline)
1)MOA
2)Use
3)Toxicity

Back 11

1) blocks M1 receptors on Mast Cells to prevent H2 release, and blocks M3 receptors on Parietal Cell to prevent HCl release

2) Peptic Ulcers

3)Bradycardia, Dry Mouth, Inability to focus vision

Front 12

Infliximab
1)MOA
2)Use
3)Toxicity

Back 12

1)Monoclonal Ab to TNF-alpha which is proinflammatory

2) Crohn's Disease, and Rheumatoid Arthritis

3) Respiratory Infxn, Fever, Hypotension

Front 13

Sulfasalazine
1)MOA
2)Use
3)Toxicity

Back 13

1)Part sulfa Abx, part anti-inflammatory

2)Ulcerative Colitis, and Crohn's Disease

3)Malaise, Nausea, Sulfa Allergy, Oligospermia

Front 14

Odansetron
1)MOA
2)Use
3)Toxicity

Back 14

1)Blocks 5-HT in the vomiting centers
2)Control post-op vomiting and cancer chemotherapy vomiting

3) Headache, Constipation

Front 15

Antacid Over Use
1)General Effect
2)Aluminum Hydroxide Effect
3)Magnesium Hydroxide Effect
4)Calcium Carbonate effect

Back 15

1) Decrease availability, excretion, or activation of various other drugs
2)Constipation and hypophosphatemia (aluMINIMUM poop)
3)Diarrhea (Mg= must go)
4)Hypercalcemia, acidosis

ALL CAUSE HYPOKALEMIA

Front 16

Prokinetics (Metoclopromide, Cisapride)
1)MOA
2)Use
3)Toxicity

Back 16

1) Increases gastric motility
2)GERD
3) Nausea, Torsades de Pointe, high cyclophosphamide, low L-Dopa