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16 Cards in this Set

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H2 Blockers

1)Names
2)MOA
3)Use
4)Toxicity
1)Cimetidine, Rinitidine, Nizatidine

2) Reversible block of Histamine receptors, causing decreased secretion of HCl from Parietal cell (blocks synergistic effect)

3)Peptic Ulcers, Gastritis, esophageal reflux

4) Cimetidine inhibits p450, antiadrogenic effect, and BLOCKS CREATININE seretion
Proton Pump Inhibitors
1)Names
2)MOA
3)Uses
4)Side Effect
1)Omeprazole, Lansoprazole
2)Irreversibly inhibit H+/K+ pump in parietal cells

3)Peptic ulcers, gastritis, Reflux, Zollinger-Ellison syndrome (excess gastrin)

4)decreases Phenytoin excretion
Bismuth, Sucralfate
1)MOA
2)Use
3)Toxicity
1)Binds ulcer base to provide protection, and allows HCO3- to reestablish pH gradient

2)Ulcer healing, and part of triple therapy, Diarrhea

3)Prevents absorption of Quinilones and Tetracyclines
Triple Therapy
Metronidazole, Bismuth, Amoxicillin (Tetracycline)
Misoprostol
1)MOA
2)Use
3)Toxicity
1)PGE1 analog to increase secretion of HCO3- and decrease acid secretion

2)Prevents NSAID induced ulcers, keeps patent ductus arteriosis open, and can induce labor

3)Diarrhea, causes abortion
HMG CoA Reductase (Statins)
1)MOA
2)Effect on LDL, HDL, TAGs
3)Side Effects
1) Prevents synthesis of new cholesterol in the liver by blocking HMG-CoA Reductase (rate limiting step)

2)Drops LDL the most, slight increase in HDL, minor decrease in TAG

3)Expensive, reversible increase in LFTs, myositis
Niacin
1)MOA
2)Effect on LDL, HDL, TAGs
3)Side Effects
1)Prevents release of formed VLDLs from liver

2)decreases LDL, increases HDL, minor decrease in TAG

3) Red, flushed face (prevented by aspirin)
Bile Acid Resins
1)MOA
2)Effect on LDL, HDL, and TAG
3)Toxicity
1) Binds bile acids in the intestines and causes them to be excreted. This causes de nova synthesis from endogenous cholesterol to deplete stores

2) Lowers LDL significantly, no effect on HDL, and slightly increases TAGs

3) Tastes bad and causes diarrhea
Cholesterol Blockers- Ezetimibe

1)MOA
2)Effects on LDL, HDL, and TAGs
3)Toxicity
1)Prevents absorption of dietery cholesterol
2) lowers LDL only
3)Rare increase in LFTs
Fibrates (gefimbrozil, clofibrate, fenofibrate)
1)MOA
2)LDL,HDL,TAGs
3)Toxicity
1)Blocks Lipoprotein Lipase in the periphery
2)Lowers LDL, increase HDL, massive decrease in TAG
3)Myositis, and increased LFTs
Muscarinic Blockers (Pirenzepine, propantheline)
1)MOA
2)Use
3)Toxicity
1) blocks M1 receptors on Mast Cells to prevent H2 release, and blocks M3 receptors on Parietal Cell to prevent HCl release

2) Peptic Ulcers

3)Bradycardia, Dry Mouth, Inability to focus vision
Infliximab
1)MOA
2)Use
3)Toxicity
1)Monoclonal Ab to TNF-alpha which is proinflammatory

2) Crohn's Disease, and Rheumatoid Arthritis

3) Respiratory Infxn, Fever, Hypotension
Sulfasalazine
1)MOA
2)Use
3)Toxicity
1)Part sulfa Abx, part anti-inflammatory

2)Ulcerative Colitis, and Crohn's Disease

3)Malaise, Nausea, Sulfa Allergy, Oligospermia
Odansetron
1)MOA
2)Use
3)Toxicity
1)Blocks 5-HT in the vomiting centers
2)Control post-op vomiting and cancer chemotherapy vomiting

3) Headache, Constipation
Antacid Over Use
1)General Effect
2)Aluminum Hydroxide Effect
3)Magnesium Hydroxide Effect
4)Calcium Carbonate effect
1) Decrease availability, excretion, or activation of various other drugs
2)Constipation and hypophosphatemia (aluMINIMUM poop)
3)Diarrhea (Mg= must go)
4)Hypercalcemia, acidosis

ALL CAUSE HYPOKALEMIA
Prokinetics (Metoclopromide, Cisapride)
1)MOA
2)Use
3)Toxicity
1) Increases gastric motility
2)GERD
3) Nausea, Torsades de Pointe, high cyclophosphamide, low L-Dopa