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24 Cards in this Set
- Front
- Back
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Salivary & pancreatic secretions regulated by…
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Extrinsic NS
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Intestinal & gastric acid secretions regulated by
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Intrinsic & Extrinsic NS
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Fluid into GI tract (amount & sources)
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9 L
2 L ingested secreted via: gastric = 2000 ml saliva, pancreatic, SI = 1500 ml each bile = 500 ml |
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Fluid absorbed from GI tract
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8500 ml in SI (8.5 L)
400 ml in colon 100 excreted in feces |
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Primary control of salivary secretions
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Parasympathetic NS
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Excitatory triggers of salivary secretion
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Conditioned reflex (Pavlov)
Sight & sound of food Vomiting Smell, taste, pressure |
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Inhibitory triggers of salivary secretion
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Sleep
Dehydration Fear Fatigue |
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Integration of salivary stimuli occurs…
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Medulla, salivary nucleus
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Cranial nerves for salivary secretion
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VII- lingual & submandibular
Via submandibular ganglion IX- parotid Via otic ganglion |
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Salivary secretion will be watery with stim from …
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Ach on M3’s
Increases PKC & rls Ca Also requires vasodilate Via ACh on M3’s, Ca & ENOS |
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Vasodilation mediated by
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ACh on M3’s, increase Ca increases ENOS
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Salivary secretion will be amylase rich from…
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Sympathetic stim
NE increases aciner secretion Acts on Beta 2s- AC & cAMP |
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Prolonged sympathetic stim to salivation…
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(beta 2’s increase amylase via cAMP)
alpha 1’s vasoconstrict via PLC (reduce secretion) |
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Stimulus on pancreatic secretions during cephalic phase
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Vagus efferents
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Stimulus on pancreatic secretions during gastric phase
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Vagovagal reflex (vagal a’s & e’s)
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Vagovagal reflex for pancreatic secretion
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Vagal a’s sense fat in SI
Integrated in BS Continue e’s stim secretion |
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Vagal efferents mechanism for pancreatic secretion
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ACh on M3’s of acinars & duct & G cells
Increases Ca |
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Stimulus on pancreatic secretions during intestinal phase
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Secretin & CCK potentiated by vagovagal response
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Secretomotor response in gastric secretions
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Intrinsic & extrinsic
I=VIP signals increase Cl ACh signals Ca activation of Cl chan (K out) E=ACh to submucosal complex NE to alpha 1 to constrict & alpha 2 To shut down N (increase absorption) |
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Intrinsic secretomotor response in stomach
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VIP signals increase in Cl
ACh signals Ca activation of Cl channel (K out) |
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Extrinsic secretomotor response in stomach
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Para’s to submucosal comples
ACh on N R’s (not direct innervation) Symp’s to blood vessels NE on alpha 1 to constrict, alpha 2 to shut down Ns & increase absorption |
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Directors of acid secretion in cephalic phase
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Vagal stim to enteric
ACh to M3 on parietal GRP to GRP R on G cells (endocrine amplification) |
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Directors of acid secretion in gastric phase
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Local & Long Pathways
Local: Distention, ENS sense, signal, rls ACh to G & Parietal cell Long: Vagovagoreflex, augments responses |
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Stimulants of acid secretion
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Histamine- paracrine
Gastrin- hormone ACh |
