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24 Cards in this Set

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  • Back
Salivary & pancreatic secretions regulated by…
Extrinsic NS
Intestinal & gastric acid secretions regulated by
Intrinsic & Extrinsic NS
Fluid into GI tract (amount & sources)
9 L
2 L ingested
secreted via:
gastric = 2000 ml
saliva, pancreatic, SI = 1500 ml each
bile = 500 ml
Fluid absorbed from GI tract
8500 ml in SI (8.5 L)
400 ml in colon
100 excreted in feces
Primary control of salivary secretions
Parasympathetic NS
Excitatory triggers of salivary secretion
Conditioned reflex (Pavlov)
Sight & sound of food
Vomiting
Smell, taste, pressure
Inhibitory triggers of salivary secretion
Sleep
Dehydration
Fear
Fatigue
Integration of salivary stimuli occurs…
Medulla, salivary nucleus
Cranial nerves for salivary secretion
VII- lingual & submandibular
Via submandibular ganglion
IX- parotid
Via otic ganglion
Salivary secretion will be watery with stim from …
Ach on M3’s
Increases PKC & rls Ca
Also requires vasodilate
Via ACh on M3’s, Ca & ENOS
Vasodilation mediated by
ACh on M3’s, increase Ca increases ENOS
Salivary secretion will be amylase rich from…
Sympathetic stim
NE increases aciner secretion
Acts on Beta 2s- AC & cAMP
Prolonged sympathetic stim to salivation…
(beta 2’s increase amylase via cAMP)
alpha 1’s vasoconstrict via PLC (reduce secretion)
Stimulus on pancreatic secretions during cephalic phase
Vagus efferents
Stimulus on pancreatic secretions during gastric phase
Vagovagal reflex (vagal a’s & e’s)
Vagovagal reflex for pancreatic secretion
Vagal a’s sense fat in SI
Integrated in BS
Continue e’s stim secretion
Vagal efferents mechanism for pancreatic secretion
ACh on M3’s of acinars & duct & G cells
Increases Ca
Stimulus on pancreatic secretions during intestinal phase
Secretin & CCK potentiated by vagovagal response
Secretomotor response in gastric secretions
Intrinsic & extrinsic
I=VIP signals increase Cl
ACh signals Ca activation of Cl chan
(K out)
E=ACh to submucosal complex
NE to alpha 1 to constrict & alpha 2
To shut down N (increase absorption)
Intrinsic secretomotor response in stomach
VIP signals increase in Cl
ACh signals Ca activation of Cl channel (K out)
Extrinsic secretomotor response in stomach
Para’s to submucosal comples
ACh on N R’s
(not direct innervation)
Symp’s to blood vessels
NE on alpha 1 to constrict, alpha 2 to shut down Ns & increase absorption
Directors of acid secretion in cephalic phase
Vagal stim to enteric
ACh to M3 on parietal
GRP to GRP R on G cells (endocrine amplification)
Directors of acid secretion in gastric phase
Local & Long Pathways
Local:
Distention, ENS sense, signal, rls
ACh to G & Parietal cell
Long:
Vagovagoreflex, augments responses
Stimulants of acid secretion
Histamine- paracrine
Gastrin- hormone
ACh