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33 Cards in this Set

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ground glass inclusions
Hep B virus
nodular lymphoi aggregates
Hep C virus
female
3-4 decade
oral contraceptive use
anabolic steroids
Hepatic adenoma: non maling non cirrohtic
asymp
ab pain/ discomfort; hemorage or necrossi
shcok secondary to intraperitoneal rupture of the tumor
hepatic adenoma
Dx of hepatic adenoma:
gold standard: biopsy and resection of tumor
solitary well circumscribed mass (not encapsulated)
absenec of normal portal tract structures
clonal proliferation of hepatocytes
hepatic adenoma
tx and prog of hepatic adenomas:
one
multi
cell atypia
one: resect or watch
multi: close follow up; liver transplant
complete resection: evaluate for HCC
benign
young women
altered vasculature
focal cirrhosis
FNH
abnormal poral strucrure
associated with profound ductular proliferation and inflammation
central area of scarring and areas of normal looking vascualture
FNH
large cell changes:
hyperchromatic nuclei
multinucleated
not pre malig, but associate;
low grade dysplastic
small cell changes:
hydperchromatic nulcei
increased N:C ratio
cells form nodules within nodules in liver
pre malignant
what is the most common malignancy found in the liver?
metastases; usually metastatic carcinoma from colon pancreas lung breast
what is the most common primary malignancy of the liver?
Hepatocellular carcinoma HCC
male
mild ab pain
wt loss
jauncie
ascites
malaise
clinical present of HCC
know cirrhotic pt with sudden decomp:
think about new tumor
increase serum alpha feto-protein:
can be over 1000 in large tumors
are AIH and Wilson's associated with HCC
rarely
what is the most common pediatric tumor?
hepatoblastoma
still rare though
wnt/b catenin signal activation
FoxG1 expression
mix of epithelai and mesnchymal areas
hepatoblastoma
polyvinyl chloride exposure
blood lakes
thickend stroma
plump pleomorphic endo cells
Angiosarcoma: malignant
what are von meyenburg complexes?
hamartomas
sporadic
slight association wi AD PKD
von meyenburg complex
AR
stron associatoin w/ AD PKD
younger people
gigher risk of chlangiosarcoma
congenitla hepatic fibrosis
dialtio of intr and extra hepatic biliary tree
pain
associat with both PKDs
Caroli disease
incre risk of carcinoma
caroli syndrom
caroli dieasese in the setin of congenital hepatic fibrosis
multifocular with mucinous serous or prulent matirel
smoth trabecualted linin of cyst
stroma looks like ovarie
dosnt communicate with billiary tree
biliary cystadenoma
what is the 2nd most common primary malignancy of the liver
Cholangiocarcinoma
highly aggressive and dismal survivla
what are some assoiations of Cholangiocarcinoma?
PSC parsitic infection, cystic disease of biliary tree
what is the tumor marker for Cholangiocarcinoma?
CA19.9
mild to sever cytologic atypia,
intracytoplasmic lumina
incrased N:C ratio
increased mitoses
fibrous stroma
Ductal type Cholangiocarcinoma
rare, papillary gorwth into the bile duct lumen,
lined by columar epit
infrequent mitoses,
papillary type Cholangiocarcinoma
females,
late 50s
rare
body or fundus of gland
mostly tubular, papillary is worse
adenomas of gallbladder
size= malignancy
femael
elderly
rare
fundus
uppper abdominal pain
increase alk phos
ASSociated with: gallstones, FAP, procellain gallbladder
gallbladder adenocarcinoma