Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
33 Cards in this Set
- Front
- Back
|
ground glass inclusions
|
Hep B virus
|
|
|
nodular lymphoi aggregates
|
Hep C virus
|
|
|
female
3-4 decade oral contraceptive use anabolic steroids |
Hepatic adenoma: non maling non cirrohtic
|
|
|
asymp
ab pain/ discomfort; hemorage or necrossi shcok secondary to intraperitoneal rupture of the tumor |
hepatic adenoma
|
|
|
Dx of hepatic adenoma:
|
gold standard: biopsy and resection of tumor
|
|
|
solitary well circumscribed mass (not encapsulated)
absenec of normal portal tract structures clonal proliferation of hepatocytes |
hepatic adenoma
|
|
|
tx and prog of hepatic adenomas:
one multi cell atypia |
one: resect or watch
multi: close follow up; liver transplant complete resection: evaluate for HCC |
|
|
benign
young women altered vasculature focal cirrhosis |
FNH
|
|
|
abnormal poral strucrure
associated with profound ductular proliferation and inflammation central area of scarring and areas of normal looking vascualture |
FNH
|
|
|
large cell changes:
|
hyperchromatic nuclei
multinucleated not pre malig, but associate; low grade dysplastic |
|
|
small cell changes:
|
hydperchromatic nulcei
increased N:C ratio cells form nodules within nodules in liver pre malignant |
|
|
what is the most common malignancy found in the liver?
|
metastases; usually metastatic carcinoma from colon pancreas lung breast
|
|
|
what is the most common primary malignancy of the liver?
|
Hepatocellular carcinoma HCC
|
|
|
male
mild ab pain wt loss jauncie ascites malaise |
clinical present of HCC
|
|
|
know cirrhotic pt with sudden decomp:
|
think about new tumor
|
|
|
increase serum alpha feto-protein:
|
can be over 1000 in large tumors
|
|
|
are AIH and Wilson's associated with HCC
|
rarely
|
|
|
what is the most common pediatric tumor?
|
hepatoblastoma
still rare though |
|
|
wnt/b catenin signal activation
FoxG1 expression mix of epithelai and mesnchymal areas |
hepatoblastoma
|
|
|
polyvinyl chloride exposure
blood lakes thickend stroma plump pleomorphic endo cells |
Angiosarcoma: malignant
|
|
|
what are von meyenburg complexes?
|
hamartomas
|
|
|
sporadic
slight association wi AD PKD |
von meyenburg complex
|
|
|
AR
stron associatoin w/ AD PKD younger people gigher risk of chlangiosarcoma |
congenitla hepatic fibrosis
|
|
|
dialtio of intr and extra hepatic biliary tree
pain associat with both PKDs |
Caroli disease
incre risk of carcinoma |
|
|
caroli syndrom
|
caroli dieasese in the setin of congenital hepatic fibrosis
|
|
|
multifocular with mucinous serous or prulent matirel
smoth trabecualted linin of cyst stroma looks like ovarie dosnt communicate with billiary tree |
biliary cystadenoma
|
|
|
what is the 2nd most common primary malignancy of the liver
|
Cholangiocarcinoma
highly aggressive and dismal survivla |
|
|
what are some assoiations of Cholangiocarcinoma?
|
PSC parsitic infection, cystic disease of biliary tree
|
|
|
what is the tumor marker for Cholangiocarcinoma?
|
CA19.9
|
|
|
mild to sever cytologic atypia,
intracytoplasmic lumina incrased N:C ratio increased mitoses fibrous stroma |
Ductal type Cholangiocarcinoma
|
|
|
rare, papillary gorwth into the bile duct lumen,
lined by columar epit infrequent mitoses, |
papillary type Cholangiocarcinoma
|
|
|
females,
late 50s rare body or fundus of gland mostly tubular, papillary is worse |
adenomas of gallbladder
size= malignancy |
|
|
femael
elderly rare fundus uppper abdominal pain increase alk phos ASSociated with: gallstones, FAP, procellain gallbladder |
gallbladder adenocarcinoma
|
