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3 Cards in this Set
- Front
- Back
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Which polyposis syndromes are characaterized by hamartomatous polyps?
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1. Peutz-Jeghers Syndrome: Mucocutaeneous hyperpigmentation, increased risk of gastroduodenal and colon malignancy and extraintestinal neoplasms (ovarian, testicular, breast)
2. Cowden disease: thyroid and breast abnormalities. 3. Cronkhite-Canada syndrome: loss of hair and nails as well as hyperpigmentation. 4. Juvenile polyps: NOTE: polyps may serve as lead points for intussusception. |
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1. Which polyposis syndromes are characterized by adenomatous polyps in the small bowel and colon?
2. What is the nature of the polyps in the stomach in these polyposes syndromes? |
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- Familial adenomatous polyposis (FAP): - Gardner syndrome: desmoid tumors, osteomas, epidermoid cysts, papillary thyroid cancer. - Turcot syndrome: CNS tumors (gliomas and medulloblastomas) - Hereditary nonpolyposis colon cancer syndrome (Lynch syndrome): DNA mismatch repair mutation resulting in increased incidence of a variety of malignancies. 2. The polyps in the stomach are hyperplastic. |
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What is Cowden disease?
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Polyposis syndrome characterized by hamartomas.
Only polyposis syndrome to give multiple esophageal polyps. |
