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17 Cards in this Set
- Front
- Back
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What is the most defining symptom of enterohemorrhagic E. coli?
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hemorrhagic colitis (bloody stool that looks cranberry sauce)
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What strain of E. coli is responsible for food outbreaks?
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E. coli 0157
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How is enterohemorrhagic E. coli transmitted?
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Unpasteurized (RAW=BAD) milk/cheese
howard county FAIR! petting zoos dairy farms (cow poop) DON'T GO TO THE FAIR! |
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What population group is most affected by EHEC?
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KIDS (at the fair)
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What toxin makes EHEC (0157) so very bad?
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Shiga-like toxin aka verotoxin
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What is the major sequelae due to Shiga-like toxin?
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Hemolytic Uremic Syndrome (HUS)
HUS causes acute renal failure in KIDS! |
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How would you diagnose HUS?
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1. MAHA (MicroAngiopathic Hemolytic Anemia): damage to glomerular microvasculature
2. Thrombocytopenic purpura 3. Acute renal failure 4. Young kids 5. Caused by 0157 EHEC's shiga-like toxin 6. primary target: renal microvasculature |
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Should you give antibiotics to patients with EHEC infection?
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NO!!!!!
Abx will make MORE Shiga-like toxin! |
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Does C. dif use spores?
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Yes
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What are the two toxins associated with C. dif and what do they do?
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Toxin A: screws up tight junctions in enterocytes so that crap leaks out of cell (and B can get in too?); stimulates release of Substance P, Neurotensin, Calcitonin gene-related peptide. Now you get secretagogues activated-->Cl- secretion and H2O loss
Toxin B: enters from basolateral side INDUCES APOPTOSIS |
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What is the defining clinical feature of C. dif?
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Pseudomembranous colitis
plaques! |
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Is C. dif part of normal flora?
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Yes
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What kind of food might have C. dif in it?
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poultry
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How are toxins A and B different from cholera/listeria toxin?
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Toxins A and B cause inflammation and fluid secretion; CT/LT do not.
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What are the 5 Ps of EPEC?
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1. Pathogenic
2. Pedestal (caused by attaching and effacing lesions; decreases absorptive surface area) 3. Persistent diarrhea 4. Pili 5. Peds |
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What is the colonization pattern that you'd see with EAEC?
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Bricks!
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In what kind of population will you most likely see EAEC?
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1. HIV/AIDS
2. kids in poor countries |
