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12 Cards in this Set
- Front
- Back
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Gastrin
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Source: G cells
Target: parietal cells Function: increase acid secretion, histamine release Regulation: vago-vagal, amino acids, peptides |
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CCK
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Source: I cells
Target: CCK1/2 receptors in small intestine Function: stimulate gall bladder, exo/endo pancreas, inhibit gastric emptying Regulation: peptides, amino acids, FAs > 8 carbons |
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Secretin
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Source: S cells
Target: pancreas, bile ducts Function: release HCO3, pepsin, inhibit gastric acid secretion Regulation: acid, (fat) |
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VIP
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Source: neurotransmitter
Target: small intestine, pancreas, gall bladder Function: vasodilation, exo pancreas, relaxes smooth muscle Regulation: none |
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GLP-1
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Source: L cells
Target: pancreas, stomach Function: increase insulin secretion during hyperglycemic conditions, decrease gastric secretion/emptying Regulation: glucose, fat |
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Motilin
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Source: mucosal cells in duodenum, jejunum
Target: migrating myoelectric complex (MMC) Function: stimulate MMC Regulation: interdigestive phase (just before/during wave of motility) |
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Pancreatic polypeptide
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Source: pancreas
Target: pancreas, gall bladder Function: decrease exo pancreas, decrease gall bladder contraction, decrease intestinal motility Regulation: protein, (fat, glucose) |
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Peptide YY
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Source: ileum, colon
Target: stomach Function: decrease gastric emptying/secretion Regulation: fat |
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Neuropeptide Y
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Source: CNS
Target: Alpha cells of pancreas Function: increase food intake Regulation: glucose, fat |
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Somatostatin
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Source: D cells
Target: nearby cells (paracrine) Function: inhibit everything (exo/endo pancreas, blood flow) Regulation: acid, inhibit by vagus |
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Histamine
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Source: ECL cells
Target: parietal cells Function: acid secretion Regulation: Gastrin |
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Enkephalins
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Source: mucosa, SM
Target: SM, sphincters Function: contraction Regulation: none |
