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21 Cards in this Set
- Front
- Back
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what cells secrete cholecystokinin?
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I cells
(duodenum, jejunum) |
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Whats does CCK do?
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Increase pancreatic secretion
increase gall bladder contraction decrease gastric opening |
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stimulant for CCK release?
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Fatty acids,
amino acids |
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which cells release secretin?
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S cells
(duodenum) |
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what does secretin do?
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increase pancreatic bicarb
lower gastric acid secretion increase bile secretion |
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what stimulates secretin release?
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acid, fatty acids in duodenum
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which cells release somatostatin?
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D cells (pancreatic islets, GI mucosa)
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what does somatostatin do?
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decrease gastric acid secretion
lower pancreatic and intestinal fluid secretion lower gall bladder contraction lower insulin and glucagon release |
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what stimulates somatostatin release?
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acid
inhibited by vagal stimulation |
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Gastric inhibitory Peptide (GIP) or Glucose dependent Insulinotropic peptide.
Which cells release it? |
K cells (duodenum, jejunum)
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what does GIP do?
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lower acid secretion,
increase insulin release |
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what stimulates GIP release?
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fatty acids, amino acids and glucose
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Vasoactive intestinal polypeptide (VIP)
where released? |
parasymp. ganglia insphincters, gall bladder and small intestines
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what does VIP do?
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increase intestinal water and electrolyte secretion
increase relaxation of intestinal smooth muscle and sphincters. |
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what stimulates VIP release?
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distention, vagal stimulation,
decreased by adrenergic input |
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NO- what does it cause?
loss of No secretion in LES? |
causes smooth muscle relaxation
Achalasia |
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motilin? what does it do?
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MMMC during fasting
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metoclopramide
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dopamine receptor antagonist, prokinetic. Use in gastroparesis
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lactulose
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digested by colonic bacteria, turns environment acidic, protonates ammonia to make it less absorbable. prevents hepatic encephalopathy
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Neomycin
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destroy gut flora, less of them to make ammonia.
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Loperamide, meperidine and diphenoxylate
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opiod agonists constrict smooth musclle, prevent diarrhea. Use in irritable bowel
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