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17 Cards in this Set
- Front
- Back
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What is secreted by the stomach
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IF, pepsinogems, lipase mucus, etc
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what happens to a stimulated parietal cell?
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major cellular remodeling; canaliculi protrude and increase surface area
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how does gasticr juice comp. change with flow rate?
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At low flow rates Cl and Na are high, H is low
At high flow CL increases, H increases, Na decreases K stays about the same |
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What can chronic vomitting do to teeth?
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demineralize bc stomach contains acid at lethal concentrations
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what is the key player (ion channel) of parietal acid secreting cell?
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H-K pump
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how do yyou shut down acid secretion?
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as acid concentration rises, SS cells secrete somatistatin and turn of G cell (gastrin secreting)
Paracrine relationship |
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how is acid initially secreted?
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when you think about food, vagal stimulation--> ACh -GRP stimulation of G cells to produce gastrin and histamine
result is active transport H/K ATPase then somatostain turns off gastrin realsese and turns of acid production |
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What secretes mucus?
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surface epithelial cells and mucous neck cells
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what causes mucus secretion?
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vagal efferent stimulation
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what is the role of mucus
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lubircate
maintain pH at 7 and prevent autodigestion |
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what secretes pepsinogen?
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chief cells group 1 in oxyntic gland
mucous cells of pyloric glands group II |
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what is pepsinogen cleaved to?
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pepsin (by pepsin and acid)
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What sitmulates pepsinogen secretion?
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vagal efferents and enteric cholinergic reflex
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what does pepsinogen do?
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cleaves internal peptide bonds
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what is released in response to secretin in the duodenum?
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Pepsinogen
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What is Intrisnic Factor?
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its a mucoprotein secreted by parietal cells that is essential for the absorption of Vita B12
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what can a deficiency of IF lead to ?
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pernicious anemia
you have to be able to absorb B12 to live! IF is essential to life! |
