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17 Cards in this Set
- Front
- Back
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What two factors can trigger the start of steatosis leading to cirrhosis?
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Alcohol abuse and/or metabolic syndrome
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How can you detect steatosis on CT?
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Fatty liver is hypodense (darker) in comparison to the spleen. It should normally be brighter (hyperdense) relative to the spleen.
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With early/mild steatosis, where is fat deposition seen within the liver?
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centrilobular hepatocytes, sparing the periportal zone
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With severe steatosis, which region of the liver is fat deposition seen?
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The entire lobule may be affected.
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True or False: Fibrosis is not seen in steatosis or steatohepatitis
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FALSE
In severe steatosis w/ early steatohepatitis, fibrosis is perisinusoidal and chicken wire-like from central venule. |
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Flashback! What two things are needed for cirrhosis?
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thick fibrous bands and regenerative nodules
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T or F: Steatosis may not be identifiable in chronic steatohepatitis w/ cirrhosis.
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TRUE
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Fill in the missing step: chronic EtOH use --> increased absorption of endotoxin from gut --> ____ --> EtOH liver dz.
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endotoxin transported to liver by portal vein; activates Kupffer cells w/ cytokine release
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Fill in the missing step: chronic EtOH use --> EtOH metabolism requires heavy O2 consumption --> ____ --> EtOH liver dz
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centrilobular hepatocytes more sensitive to hypoxic injury
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How is Mallory's Hyaline formed?
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EtOH metabolized to acetaldehyde --> binds to hepatocyte cytoplasmic proteins --> induces clumping of cytokerratin filaments
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Marked hepatocyte ballooning w/ abundant Mallory's hyaline makes you think of what?
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alcoholic steatohepatitis
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How can you distinguish ASH from NASH from a path section alone?
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you can't!
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T or F: Mallory bodies are specific for FLD
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FALSE:
They should make you think about AFLD, but they can be seen in Wilson's, PBC, HCC, chronic cholestatic conditions |
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Macrovesicular steatosis with AST:ALT < 1 makes you think of what?
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NAFLD
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Macrovesicular steatosis with AST:ALT > 2 makes you think of what?
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AFLD
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How do you distinguish b/w steatosis and steatohepatitis using radiographs?
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you can't! you can only see the fatty liver
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Eosinophils in a liver bx make you think of what?
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drug induced hepatitis
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