Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
25 Cards in this Set
- Front
- Back
|
PPI prototype
|
omeprazole or prilosec
|
|
|
what is so great about omeprazole
|
most effective for suppressing acid, well tolerated and cheap, better than H2, suppress basal and stimulated acid
|
|
|
PPI indications
|
GERD and PUD
|
|
|
2 important stuff about mechanisms of omeprazole
|
prodrug- converts with parietal cells
affect is not reversible leaves system 3-5 days |
|
|
where does omeprazole absorbed?
|
in the duodenum because it acid labile
|
|
|
bad things about omeprazole
|
use only 4-8 weeks long-term use can cause stomach cancer and osteoporosis
|
|
|
drug interactions with omeprazole
|
aids drugs and anti fungal
|
|
|
What is GERD?
|
heartburn and acid regurg it id defined as gastic contents in the esophagous
|
|
|
types of GERD
|
NERD and erosive - less than 50% have erosive
|
|
|
What causes GERD?
|
sphincter problems (LES), has nothing to do with H. pylori
|
|
|
what life style changes can help GERD?
|
stop smoking, drinking, loss weight, avoid sleeping with head elevated, and late night meals
|
|
|
what does sucralfate do?
|
promotes ulcer healing by creating protective layer
|
|
|
what does sucrafate not do?
|
neutralize acid
|
|
|
how long does sucralfate stick to ulcers and what pH does it require?
|
6 hours and <4
|
|
|
how is sucralfate different than other drugs
|
doesnt get absorbed- so there are no side effects.
|
|
|
drug interaction concerns for sucralfate -2
|
it doesn't work in >4 pH so take an antacid 30 min apart
impede absorption of drugs of some drugs so take 2 hours apart. |
|
|
special administration issue with sucralfate
|
much dissolve in 30 cc- sticks to only active ulcers
|
|
|
what is the indications of misoprostol?
|
NSAID induced ulcers, cervical ripening and induce abortion
|
|
|
another name for misoprostol
|
prosaglandin
|
|
|
what does misoprostol do?
|
suppresses acid, increase blood flow, and promotes mucous
|
|
|
Antacids indications
|
PUD and GERD
|
|
|
3 things that antacids do
|
help prosraglandin secretion, neuralize acids to make salt, and reduce pepsin when pH >5
|
|
|
potential immediate reaction to antacids
|
belching of CO2 can cause aspiration
|
|
|
multiple medications with antacids
|
wait 1 hour apart
|
|
|
different antacids can cause different SE
|
Mg- diarrhea
Al- constipation- can mix these two together some have high salt content which can cause problems with CV |
