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31 Cards in this Set
- Front
- Back
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Defensive factors in the battle of PUD
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mucus, bicarb, blood flow, prostaglandins
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Aggressive factors in the battle of PUD
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#1H. pylor, #2 NSAIDS, Acid, pepsin, Smoking
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how do prostaglandins help against PUD?
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increase mucus production and bicarb, they vasodilate, and suppress gastric acid secretion
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How do NSAIDS cause PUD?
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by inhibiting protaglandins
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5 types of drugs to treat PUD
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antibiotics, antisecretory, muscoul protectants, ASA that enhance mucous, antacids
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what needs to be added to antibiotics for treating pylori?
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PPI
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what is the preferred for NSAID PUD prophylaxis
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PPI- omeprazole
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treatment for NSAID PUD
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miso
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weird way to test for pylori
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breath test for ammonia
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pH of stomach
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1.3
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pH perferences of pepsin and what most pH raising drugs shoot for?
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pepsin activity 4x at 2 and deactivates at 5
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diet modifications for PUD
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several small meals, - no ulcer diet
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antibiotic protocol for killing pylori
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use 2 or 3 w/ PPI for 4 days
N+V common, 12 pills, expensive= noncompliance |
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1st choice for treating gastric ulcers
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H2
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how do H2 work?
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suppressing secretion of gastric acid
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H2s end in -____
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-ine
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why is cimetidine no the protocal drug for H2
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stomach cancer, drug interactions and expense, fewer SE, less potent, cause antiandrogenic
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cool things with ranitidine
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eat with food, not enter cns,
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who is at risk for taking H2?
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liver and kidney disease
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precautions with H2 and antacid interaction
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at least 1 hour apart. antacids decrease absorption of H2
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H2s end in -____
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-ine
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why is cimetidine no the protocal drug for H2
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stomach cancer, drug interactions and expense, fewer SE, less potent, cause antiandrogenic
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cool things with ranitidine
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eat with food, not enter cns,
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who is at risk for taking H2?
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liver and kidney disease
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precautions with H2 and antacid interaction
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at least 1 hour apart. antacids decrease absorption of H2
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pH preferences of pepsin and what should most pH raising drugs shoot for?
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pepsin activity 4x at 2 and deactivates at 5
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diet modifications for PUD
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several small meals, - no ulcer diet
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antibiotic protocol for killing pylori
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use 2 or 3 w/ PPI for 4 days
N+V common, 12 pills, expensive= noncompliance |
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1st choice for treating gastric ulcers
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H2
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how do H2 work?
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suppressing secretion of gastric acid
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what is the H2 prototype?
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ranitidine or zantac
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