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20 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Cimetidine
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H2 blocker, reversibly inhibits histamine receptor 2, decreases H+ stimulation (H2 is Gs receptor)
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Use: Peptic ulcer, gastritis, mild esophageal reflux
Toxicity: P450 inhibitor, antiadronergic effects (prolactin release, gynecomastia, impotence, decreased libido in males); can cross BBB (confusion, dizziness, H/As) and placenta; decreased renal excretion of creatinine |
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ranitidine
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H2 blocker, reversibly inhibits histamine receptor 2, decreases H+ stimulation (H2 is Gs receptor)
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Use: Peptic ulcer, gastritis, mild esophageal reflux
Toxicity: decreased renal excretion of creatinine |
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famotidine
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H2 blocker, reversibly inhibits histamine receptor 2, decreases H+ stimulation (H2 is Gs receptor)
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nizatidine
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H2 blocker, reversibly inhibits histamine receptor 2, decreases H+ stimulation (H2 is Gs receptor)
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Omeprazole
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PPI; irreversibly inhibits H+/K+ ATPase in stomach parietal cells
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Use: Peptic ulcer, gastritis, esophageal reflux, ZE syndrome
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lansoprazole
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PPI; irreversibly inhibits H+/K+ ATPase in stomach parietal cells
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Use: Peptic ulcer, gastritis, esophageal reflux, ZE syndrome
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Bismuth
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bind to ulcer base provides physical protection, allows for HCO3- secretion to re-establish pH gradient
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Use: increase ulcer healing, traveler's diarrhea
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sucralfate
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bind to ulcer base provides physical protection, allows for HCO3- secretion to re-establish pH gradient
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Use: increase ulcer healing, traveler's diarrhea
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H Pylori Treatment
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Triple Therapy: Metronidazole,Amoxicillin (or Tetracycline) + Bismuth
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Misoprostol
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PGE1 analog that increase production and secretion of gastric mucous barrier, and decreases acid production
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Use: prevent NSAID induced PUD and maintain patent ductus arteriosus, also can induce labor
Toxicity: Diarrhea, contraindicated in women of childbearing potential |
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Pirenzepine
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blocks M1 receptor (Gq protein) on ECL cells to decrease histamine release and M3 receptors (Gq protein) on parietal cells to decrease acid secretion
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Use: peptic ulcer (rarely)
Toxicity: tachycardia, dry mouth, difficulty closing eyes |
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Propantheline
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blocks M1 receptor (Gq protein) on ECL cells to decrease histamine release and M3 receptors (Gq protein) on parietal cells to decrease acid secretion
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Use: peptic ulcer (rarely)
Toxicity: tachycardia, dry mouth, difficulty closing eyes |
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Octreotide
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Somatostatin analogue
in GI: decreases both gastric and pancreatic secretions, as well as gall bladder contraction and insulin and glucagon release (anti-growth) |
Use: acute variceal bleeds, acromegaly, VIPoma, and carcinoid tumors
Toxicity: nausea, cramps, steatorrhea |
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Magnesium Hydroxide
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antacid, can change absorption, bioavailability, or urinary excretion of drugs by altering gastric and urinary pH or by delaying gastric emptying
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Toxicity: diarrhea, hyporeflexia, hypotension, cardiac arrest, hypokalemia
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Aluminum Hydroxide
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antacid, can change absorption, bioavailability, or urinary excretion of drugs by altering gastric and urinary pH or by delaying gastric emptying
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Toxicity: constipation and hypophosphatemia, proximal muscle weakness, osteodystrophy, seizures, hypokalemia
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Calcium carbonate
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antacid, can change absorption, bioavailability, or urinary excretion of drugs by altering gastric and urinary pH or by delaying gastric emptying
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Toxicity: hypercalcemia and increases rebound acid, hypokalemia
Can chelate and decrease effectiveness of other drugs like tetracyclines |
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Infliximab
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monoclonal antibody to TNF alpha (pro-inflammatory cytokine)
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Use: Chron's Dz, RA
Toxicity: respiratory infection (reactivation of TB), fever, hypotension |
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Sulfasalazine
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combo of sulfapyridine and 5-aminosalicylic acid (Mesalazine), activated by colonic bacteria
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Use: Ulcerative colitis and Chron's Dz
Toxicity: malaise, nausea, sulfonamide toxicity, reversible oligospermia |
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Ondansetron
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5HT3 antagonist, powerful central-acting anti-emetic
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Use: control vomiting post-operatively and in patients undergoing cancer chemotherapy
Toxicity: H/A, constipation |
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Metoclopramide
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D2 antagonist, increases resting tone, contractility, LES tone, motility. Does not influence colon transport time
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use: diabetic and post-surgery gastroparesis
Toxicity: increases parkinsonian effects. restlessness, drowsiness, fatigue, depression, nausea, diarrhea. drug interaction with digoxin and diabetic agents. contraindicated in pts with small bowel obstruction |
