Gi Drugs

Front 1

CTZ has what receptors?

Back 1

M1, 5HT, H1, Mu, NK1

Front 2

vestibular receptors CMZ receptors are

Back 2

H1 and M1

Front 3

Acepromazine MOA etc

Back 3

Acts on H1 receptor
Is a phenothyazine
Dop 2 antagonist so blocks vomiting.
Also an alpha 1 and muscarinic antagonist

Front 4

Morpitant MOA etc

Back 4

NK-1 antagonist,
Approved in dogs
Acts centrally and periferally
Substance P inhibitor

Front 5

Metaclopramide

Back 5

D2 antagonist
Prokinetic
5HT 4 agonist
5HT 3 antagonist ***
Prokinetic
Acts in stomach and early GI

Front 6

To treat motion sickness

Back 6

Antihistamine
NK-1 blocker

Front 7

3 mediators of gastric acid secretion

Back 7

Gastrin, histamine and acetylcholine

Front 8

Antiemetics drug types

Back 8

Antihistamines
Phenothiazine
Antiserotonins
NK-1 Receptor blockers
Other category

Front 9

Antiemetic/antihistamine

Back 9

Diphenhydramine
Blocks H-1

Front 10

Phenothiazine antiemetic

Back 10

Acepromazine
Dopamine antagonist - anit-emetic action
Alpha 1 blocker, hist/musc blocker

Front 11

Antiserotonin antiemetic

Back 11

Onsansetron
5HT3 antagonist

Front 12

NK-1 receptor blocker antiemetic

Back 12

Maropitant
NK-1(substance P) antagonist

Front 13

Metoclopramide

Back 13

D2 antagonist,
5HT-4 agonist,
5HT-3 antagonist
pro-kinetic

Front 14

Prokinetics should not be used

Back 14

with GI blockage

Front 15

Prokinetics

Back 15

Metoclopramide
Cisapride
Bethanecol
Lidocaine
Domperidone

Front 16

Acepromazine

Back 16

Phenothiazines

Front 17

Ondansetron

Back 17

Antiserotonins

Front 18

Maropitant

Back 18

NK-1 receptor blocker

Front 19

Cisapride

Back 19

5HT-4 agonist,
5HT 3 antagonist
entire GI tract

Front 20

Bethanecol

Back 20

cholinergic agonist
entire GI and elsewhere because not specific

Front 21

Lidocaine

Back 21

local anesthetic - Na channel blocker,
unknown how it increases GI motility
Mostly horses for ileus

Front 22

Domperidone

Back 22

dopamine antagonist
Early GI
Doesn't cross BBB.

Front 23

Acid suppressant drugs

Back 23

Cimetidine
Ranitidine
Famotidine
Omeprazole
magnesium hydroxide

Front 24

H2 blockers least to most potent

Back 24

Cimetidine, Ranitidine, Famotidine

Front 25

H2 receptor MOA

Back 25

Block H2 receptors

Front 26

Proton pump inhibitors

Back 26

Omeprazole
Inhibits pump on luminal surface
Continues working in cell after Blood levels decreased

Front 27

magnesium hydroxide

Back 27

neutralizes acidic pH

Front 28

GI protective med

Back 28

Misoprostotal
synthetic PGE-1 analog
Used to prevent ulcers w/chronic NSAID use
ADE abortion

Front 29

Sucralfate

Back 29

coats stomach, protects from acid, coats edges of ulcers to promote healing, needs acidic env't to work

Front 30

Antimuscarinics:

Back 30

Atropine
Glycopyrrolate

Front 31

Antimuscarinic effect on GI tract

Back 31

decrease GI motility

Front 32

Antidiarrheal drugs

Back 32

Loperamide
Diphenoxylate

Front 33

Loperamide common name

Back 33

immodium

Front 34

Loperamide and Diphenoxylate

Back 34

Mu receptors
stop symptom, but doesn't treat problem: bacterial/viral infection

Front 35

Diphenoxylate unique characteristics

Back 35

Cross BBB
Mu receptor action, so get a high - add atropine

Front 36

If give too much Bethanecol you can give

Back 36

Atropine to counteract, but be aware of heart effects as well

Front 37

appetite stimulants

Back 37

Benzodiazepine
Cyproheptadine
Mirtazapine

Front 38

Benzodiazepine action as appetite stimulant

Back 38

potentiates effects of GABA

Front 39

Cyproheptadine MOA

Back 39

anti-serotonin and antihistamine

Front 40

Emetics

Back 40

Apomorphine
Xylazine
H2O2

Front 41

Mirtazapine

Back 41

antidepressant
A2 agonist
antihistamine
antiserotonin

Front 42

Apomorphine emetic action

Back 42

Mu agonist
stimulate dopamine receptors in CRTZ

Front 43

Xylazine emetic action

Back 43

alpha 2 agonist
used mostly in cats

Front 44

H2O2

Back 44

direct irritant effect on oropharynx/gastric lining