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39 Cards in this Set
- Front
- Back
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B. fragilis
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most resistant anaerobes
B-lactam/B-lactamase inh/cefoxitin, metronidazole GOOD |
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spontaneous
primary bacterial peritonitis |
impaired liver function
E.coli/strep/kleb 3rd cephalosporins 5-7 days |
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For primary bacterial peritonitis, in case of prophylaxis
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TMP/SMX for 5 days
ciprofloxacin once weekly |
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Abscess, ruptured bowel, cholangitis
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B.frangilis, E.coli
1/2/3 cephalosporins + metronidazole cefepime for g-/pseudo piper/tazo OR carbapen OR FQ/metronidazole |
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Acute cholecystitis
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often inflammatory only
similar approach |
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Intra-abdominal infections
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4-7 days of treatment
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Infectious diarrhea
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HYDRATE and electrodes
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Salmonella
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ciprofloxacin, ampicillin/amox, TMP/SMX, 3rd cephalosporin, azithromycin
5-7 days/immunosup >> 14 |
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Shigella
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Fluoroquinolones (nor, levo, cipro)
Amoxi/ampi TMP/SMX 3rd cephalosporins, azithro, nalidixic acid 3-5 days/immunosup >> 14 |
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E.coli
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Fluoroquinolones
TMP/SMX cepholsporins 3 days |
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Aeromonas
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TMP/SMX
ciprofloxacin 3 days |
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Vibrio cholera
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if adults, doxycycline 300mg once
if peds, tetracycline OR TMP/SMX for 3 days |
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Giardia
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Metronidazole for 7-10 days
SE >> more diarrhea |
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Travelers' diarrhea
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Hydrate the PTs first
For PEDS, no tetracyclines and cautions with flouoroquinolones |
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C. difficile
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antibacterial induced colitis - thus get off the current ones first
Metronidazole/vanco by mouth 10-14 days but it tends to come back |
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Hepatitis B
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Vaccine!
vaccine + HBVIG (antibodies) to post-exposure Interferon-alfa/lamivudine, adefovir |
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MOA of interferon-alfa
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inh of viral PRO synthesis
inh of viral penetration helps the host immune response Hep C |
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Interferon SE
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flu-like since helps host immune response
thrombocytopenia, granulocytopenia, DEPRESSION, rash |
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Hep C
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Ribavirin - inh viral RNA
SE: hemolytic anemia, renally insufficient >> pass |
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What about HCV protease inhibitors?
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telaprevir, boceprevir (CYP3A4/5 inhibitor/metabolite >> drug con. goes up in the blood)
it ups the toxicity but decreases the duration of treatment |
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Cystitis
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E.coli
3 days TMP/SMX OR Flouoro 7 days B-lactams or nitrofurantoin |
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Fosfomycin...what is it?
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it inhibits enopyruvate transferase >> cell wall synthesis gone
3g for once >> cystitis |
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Pyelonephritis
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E.coli and other G-
ORAL: FQ, 3rd cephalosporins 7-10 for uncomplicated and 14 days for majority |
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Pyelonephritis
If giving IV? |
FQ, aminoglycosides, 3rd cephs, b-lactams, carbapenems
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Bacteriuria that's not symptomatic
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Only treat pregnant women!
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Candiduria
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get foley out and stop unnecessary antibiotics
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Chancroid
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Haemophilus ducreyi
azithro 1g once ceftriaxone IM OR cipro 500mg 3 days Treat the partner, too! |
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Genital Herpes
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Gift that keeps giving...
acyclovir for 7-10 days valacyclovir 2/day constant recurrent infection gets bad >> IV acyclovir 5-10mg |
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Syphilis
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T.pallidum
treated with penicillin for all stages 1/2nd treatment: benzathine penicillin |
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Tertiary syphilis
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3 doses at 1 week interval
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Neurosyphilis
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Aq crystalline penicillin for 10-14 days
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Jarisch-Herxheimer
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For pts being treated for syphilis, they might get headache, myalgias, fever, tachycardia
ANTI-FLAMMATORY |
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Chlamydia trichomatis
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azithro 1g once
doxy 100mg for 7 days |
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Neisseria gonorrhea
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ceftriaxone 250 mg IM or cefixime 400 once
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Desseminated gonococcal infection (DGI)
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septic arthritis, endocarditis, meningitis
3rd ceph |
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Vaginosis
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metronidazole for 7 days
if fungal, fluconazole once |
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Trichomonas vaginalis
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metronidazole 2g once
metronidazole 500 bid for 7 days |
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Pelvic inflammatory disease
(PID) |
N.gonorrhea, C.trachomatis, G-, anaerobes
cefotetan/cefoxitin/doxycycline clinda+genta |
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Epididymitis
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C.trachomatis, N.gonorrhea
Ceft + doxy enteric organism >> fluoro both >> fluoro + ceftriaxone |
