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31 Cards in this Set

  • Front
  • Back
Causes of ulcer's
Bacteria
Anti-inflammatory drugs
Stress
Alcohol
Smoking
Zollinger-Ellison Syndrome
Which part of antacids cause constipation
Alluminum
Which part of antacids cause diarrhea
Magnesium
Predominant intestinal effect of antacids at high doses
Laxative
side effects of aluminum in antacids
constipation, decreased availability of tetracyclines, hypophosphatemia
Three H2 blockers, in order increasing potency
Cimetidine, Ranitidine, Famotidine
which aspect of acid secretion do H2 blockers have the most effect on
the basal secretion...stomache still responsed to food by increasing acid
stomache protectants
sucralfate, Misoprostil and Colloidal bismuth
sucralfate mechanism of gastric protection
viscous polymer that adheres to the epithelium
forms viscous polymer once in the stomache
sucralfate
side effect of sucralfate
contains aluminum so it causes constipation, low tetracycline adsorption, hypophosphatemia
Misoprostil MOA
PGE analoge to protect stomache while taking NSAIDS
SE of CI of misoprostil
crampy ab pain and diarrhea

stimulates uterine contractions, not for women who could be pregnant
Collodial Bismuth MOA
retard H diffusion and batericidal to H. pylori
Esomprazole
H/K ATPase inhibitor

binds by S-S bridge for up to 24 hours
SE of esomprazole
maybe increased bacterial infections from lower acid content
Esomprazole effect on H. Pylori
None

Must use with antibiotics
Clarithromycin + Metronidazole
Drugs from GERD
Metoclopramide, Cisapride
+ Esomprazole or H2 blockers
SE Metoclopramide
DA antagonist so EP side effects
Limitations of Metoclopramide
Side Effects
No effect on acid secretion
No effect on colon
Cisapride MOA
stimulates serotoning receptors, increasing motility

no DA activity

blocks vagal afferents to stop emesis
Motility agent that reaches the colon
Cisapride

Metoclopramide does not
SE of Cisapride
diarrhea and cardiac conduction abnormalities

Limits use of this drug
Bulk-forming laxative
methycellulose
Methycellulose
Bulk-forming laxative

add their mass and absorbed water to soften stools
Saline laxative
MgSO4

osmotic diuretic for pre-op, and colonoscopic procedures
MgSO4
Saline laxative

for pre-op and pre procedures
Stimulant laxative
Bisacodyl

very limited use
bisacodyl
stimulant laxative but too many side effects to be used
Anti-diarrheal agents
Loperamide and Diphenyoxylate

Opioids

Pepto for travelers
When to avoid opioid anti-diarrheals
In infectious or inflammatory bowel disease

Just use fluid replacement