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31 Cards in this Set
- Front
- Back
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Causes of ulcer's
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Bacteria
Anti-inflammatory drugs Stress Alcohol Smoking Zollinger-Ellison Syndrome |
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Which part of antacids cause constipation
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Alluminum
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Which part of antacids cause diarrhea
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Magnesium
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Predominant intestinal effect of antacids at high doses
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Laxative
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side effects of aluminum in antacids
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constipation, decreased availability of tetracyclines, hypophosphatemia
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Three H2 blockers, in order increasing potency
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Cimetidine, Ranitidine, Famotidine
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which aspect of acid secretion do H2 blockers have the most effect on
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the basal secretion...stomache still responsed to food by increasing acid
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stomache protectants
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sucralfate, Misoprostil and Colloidal bismuth
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sucralfate mechanism of gastric protection
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viscous polymer that adheres to the epithelium
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forms viscous polymer once in the stomache
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sucralfate
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side effect of sucralfate
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contains aluminum so it causes constipation, low tetracycline adsorption, hypophosphatemia
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Misoprostil MOA
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PGE analoge to protect stomache while taking NSAIDS
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SE of CI of misoprostil
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crampy ab pain and diarrhea
stimulates uterine contractions, not for women who could be pregnant |
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Collodial Bismuth MOA
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retard H diffusion and batericidal to H. pylori
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Esomprazole
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H/K ATPase inhibitor
binds by S-S bridge for up to 24 hours |
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SE of esomprazole
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maybe increased bacterial infections from lower acid content
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Esomprazole effect on H. Pylori
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None
Must use with antibiotics Clarithromycin + Metronidazole |
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Drugs from GERD
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Metoclopramide, Cisapride
+ Esomprazole or H2 blockers |
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SE Metoclopramide
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DA antagonist so EP side effects
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Limitations of Metoclopramide
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Side Effects
No effect on acid secretion No effect on colon |
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Cisapride MOA
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stimulates serotoning receptors, increasing motility
no DA activity blocks vagal afferents to stop emesis |
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Motility agent that reaches the colon
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Cisapride
Metoclopramide does not |
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SE of Cisapride
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diarrhea and cardiac conduction abnormalities
Limits use of this drug |
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Bulk-forming laxative
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methycellulose
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Methycellulose
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Bulk-forming laxative
add their mass and absorbed water to soften stools |
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Saline laxative
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MgSO4
osmotic diuretic for pre-op, and colonoscopic procedures |
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MgSO4
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Saline laxative
for pre-op and pre procedures |
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Stimulant laxative
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Bisacodyl
very limited use |
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bisacodyl
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stimulant laxative but too many side effects to be used
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Anti-diarrheal agents
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Loperamide and Diphenyoxylate
Opioids Pepto for travelers |
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When to avoid opioid anti-diarrheals
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In infectious or inflammatory bowel disease
Just use fluid replacement |
