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18 Cards in this Set
- Front
- Back
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Enzymes in glycogen degredation
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Glycogen phosphorylase
- Frees a G 1 P (converted to G6 via isomerase) - gives ATP for later use Debranching enzyme - two active sites - transferase (moves branch) - alpha 1-6 glucosidase (frees single G) |
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Enzymes in glycogen synthesis
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Glycogen synthetase
- for 1-4 bonds - puts UDP glucose on chain - branching enzyme |
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Major product of glycogen breakdown
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G 1 phosphate (from phosphorylase activity)
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Fate of G 6 Phosphate (from glycogen breakdown)
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Enter glycolysis in liver
Or Dephosphorylate (via G6Pase) & rls to blood Or Glycogen synth (via phosphoglucomutase) |
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Enzymes for glycogen metabolism regulated by
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Phosphorylation
- catabolic signal gives glycogenolysis - anabolic signal gives glycogenesis |
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Catabolic signal to body
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Low sugar- Glucagon
Stress/fear- Epi |
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Anabolic signal to body
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Insulin
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Glucagon affect on glycogen metabolism
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(catabolic signal)
phosphorylate Glycogen Phosphorylase (activated) via cAMP, PKA activates phosphorylase kinase allosteric regulation from b form |
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Insulin affect on glycogen metabolism
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Activate phosphoprotein phosphatase
Turns off enzyme system (inactivates a phosphorylase, phosphorylase kinase & activates glycogen synthetase by activation-phosphorylation- of phosphoprotein phosphatase) |
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Ca regulation of glycogen metabolism
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Activates glycogen phosphorylase (degrade)
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Mechanism of Von Gierke’s
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Deficiency of G6phosphatase
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Liver loaded w/glycogen (what disorder)
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Von Gierke’s
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Mechanism of Cori’s Dz
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Absence of debranching enzyme
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Accumulation of branched polysaccharide (from what disorder)
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Cori’s
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Mechanism of Anderson’s Dz
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Absence of branching enzyme
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Accumulation of unbranched polysaccharide (from what disorder)
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Anderson’s
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Mechanism of McArdle’s dz
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Absence of muscle phosphorylase
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Low exercise tolerance (from what disorder)
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McArdle’s
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