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12 Cards in this Set
- Front
- Back
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relatively common, benign, somewhat heterogeneous inherited condition presenting with mild, fluctuating hyperbilirubinemia. The primary cause is reduction in hepatic bilirubin glucuronidating activity to about 30% of normal levels
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Gilbert syndrome
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results from a hereditary defect in hepatocellular excretion of bilirubin glucuronides across the canalicular membrane. The defect is due to absence of the canalicular protein, the multidrug resistance protein 2 (MRP2; located on chromosome 10q24), that is responsible for transport of bilirubin glucuronides and related organic anions into bile.
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Dubin-Johnson syndrome
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obstruction of two or more major hepatic veins produces liver enlargement, pain, and ascites the result of increased intrahepatic blood pressure and an inability of the massive hepatic blood flow to shunt around the blocked outflow tract.
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Budd-Chiari syndrome
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what Ag do you look for for active hep B
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HBV IgM
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what Ag do you look for for active hep C
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HCV RNA
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Acute viral hepatitis what do you see microscopically
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No fibrosis but lots of lymphocytes
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what do you see microscopically with chronic hepatitis
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fibrosis (blue with tricrome)
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microscopically you see eosinophilic irregular bodies (mallory bodies) what is the dx (TEST)
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alcoholic hepatitis
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pt presents looking very tanned. He has symptoms of diabetes. Microscopic analysis of his liver with prussian blue stain shows blue Hepatocellular iron deposition.
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hemacromatosis
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Liver engorged w/ blood in absense of trauma is characteristic of this dz
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Budd-Chiari syndrome
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most common site of primary that metastesizes to liver is
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colon
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The strongest environmental influence is _______, which is believed to double the risk of pancreatic cancer,
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smoking
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