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13 Cards in this Set

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5 Types of pathogenic E. coli?
(HI PAT)

Characteristics of E. coli?
-hemorrhagic, -invasive, -pathogenic, -aggregative, -toxigenic

G- bacilli, fecal-oral
Cholera-like toxin, *T*raveler's diarrhea:

adheres to small bowel, common in (Pint-sized) children:

Shiga-like toxin, O157:H7, inflammatory colitis:
ETEC

EPEC

EHEC
Shiga-like, but no toxin, invades colonic epithelium:

in colonic mucosa, +toxin, prolonged watery diarrhea:

Which ones are non-inflammatory? (PAT)

InvAsive, inflammatory?
EIEC

EAEC

EPEC, EAEC, ETEC

EIEC, EAEC
SHIga-like?

Montezuma's Revenge?

ETEC affects what cell pathways?

What does that cause?
EHEC, EIEC

EAEC

more adenylate-cAMP, cGMP

more Cl- release, H2O follows
What's unique about EPEC's attachment to the cell? (Princess on a Pedestal)

3 stages: stick to mucosa, biofilm formation, cytotoxin, intestinal cell damage:
attaching and effacing - EPEC injects tir receptor, binds to intimin, rearranges actin in the cell --> pedestal, bacteria on top

EAEC
Has 3 stages: mucosal adherence, *biofilm*, cytotoxin/intestinal cell damage

Why is pathogenic E. coli pink on MacConkey's agar?

What E. coli are related to S(HI)gella?
EAEC

lactose fermenter

EHEC, EIEC
EHEC usually affects what systems?

Complications? (E-*H*-E-C)

Which bacteria do you AVOID ABX use? Why?
large bowel - necrosis, neutrophils
kidneys - shiga toxin

hemorrhagic colitis, HUS

EHEC - kills bacteria --> more toxin released
Major risk in maternal infection during pregnancy:

affects immunocompromised, long-term abx use, pseudomembranous colitis
L. monocytogenes

C. diff
anaerobic, G+ rod, spore forming, nonsocomial infections:

Why does C. diff cause watery diarrhea?

Tx for C. diff?
C. diff

less normal flora --> less carb digestion --> osmotic H2O into intestine

IVF, stop Abx if possible, replace normal flora
Review:
Three most common causes of acute infectious diarrhea:

causes typhoid fever:
Shigella, Salmonella, Campylobacter

Salmonella typhi
Which bacteria cause large volume, watery diarrhea? Why?

mucoid/bloody diarrhea - which bacteria? Why?
ETEC, C. perfringens, Vibrio, B. cereus, S. aureus - toxins --> more water in feces

EHEC, Shigella, Salmonella, Campylobacter, Yersinia - more invasive, leukocytes in feces, immune response
Traveled recently?

seafood lately?

systemic Abx?

mayonnaise, cream puffs?
campylobacter, E. histolytica, ETEC, salmonella, shigella, cryptosporidium

Vibrio

C. diff

S. aureus
Rice, starchy foods?

major S/S of invasive GE?

Just need toxin, not necessarily bacteria:
B. cereus

leukocytes and blood in stool, fever

S. aureus, B. cereus, C. perfringens, botulinum