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48 Cards in this Set
- Front
- Back
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Immunodeficiency:
neutrophils fail to respond to stimuli |
Jobs
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Immunodeficiency:
adenosine deaminase def |
SCID
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Immunodeficiency:
failure of endodermal development |
digorge
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Immunodeficiency:
defective tyrosine kinase |
brutons
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Immunodeficiency:
high levels of IgE |
Jobs
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difference between hexokinase and glucokinase
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hexokinase
-everywhere -low -no insulin glucokinase -high -insulin -liver/beta cells |
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blood flow in liver
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1-3
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bile flow in liver
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3-1
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what is in zone 1
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high O2
hepatic artery, vein and bile duct viral hepatitis |
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what is in zone 3
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low O2
central vein p450 alcoholic hepatitis |
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SAAG
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>1.1 = portal HTN
<1.1 = cancer, nephrotic, TB, pancreatitis, biliary disease |
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what enzyme conjugates bilirubin
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UDP glucuronyl transferase
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what drug can cause an increase in UDP glucuronyl transferase
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phenobarb
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hyperbilirubinemia:
mildly decrease UDPGT |
gilbert
CN2 |
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hyperbilirubinemia:
complete absent UDPGT |
CN1
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hyperbilirubinemia:
black liver |
dubin johnson
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hyperbilirubinemia:
responds to phenobarb |
CN2
gilbert |
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hyperbilirubinemia:
Rx with plasmaphoresis and phototherapy |
CN1
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hyperbilirubinemia:
asymptomatic unless under stress |
gilbert
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what causes budd chiari
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blocked hepatic vein or IVC
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SAAG
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>1.1 = portal HTN
<1.1 = cancer, nephrotic, TB, pancreatitis, biliary disease |
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what enzyme conjugates bilirubin
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UDP glucuronyl transferase
|
|
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what drug can cause an increase in UDP glucuronyl transferase
|
phenobarb
|
|
|
hyperbilirubinemia:
mildly decrease UDPGT |
gilbert
CN2 |
|
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hyperbilirubinemia:
complete absent UDPGT |
CN1
|
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hyperbilirubinemia:
black liver |
dubin johnson
|
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hyperbilirubinemia:
responds to phenobarb |
CN2
gilbert |
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hyperbilirubinemia:
Rx with plasmaphoresis and phototherapy |
CN1
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hyperbilirubinemia:
asymptomatic unless under stress |
gilbert
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what causes budd chiari
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blocked hepatic vein or IVC
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what conditions are associated with budd chiari
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polycythemia
pregnancy HCC |
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how does aspirin cause reyes syndrome
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inhibits beta oxidation
inhibits mitochondrial enzymes |
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if alk phosph is high, how do you confirm its because of the liver
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perform GGT
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what do you see histologically in a patient with alcoholic hepatitis
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hepatocytes
-necrotic and swollen mallory bodies -intracytoplasmic eosinophilic inclusion bodies |
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what vitamin must be supplemented in phototherapy and why
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B2
gets degraded |
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hyperbilirubinemia
presents with kernicterus |
CN1
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alcoholic cirrhosis
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irreversible
shrunken liver sclerosis around central vein |
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what are mallory bodies
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tangled bundles of cytokeratin intermediate filaments
intracytoplasmic eosinophilin inclusions |
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what drugs can cause hepatic steatosis
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stavudine
didanosine |
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marker to ID:
viral hepatitis |
ALT
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marker to ID:
alcoholic hepatitis |
AST
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marker to ID:
alcohol consumption |
GGT
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marker to ID:
obstructive liver disease |
alk phosph
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marker to ID:
pancreatitis and mumps |
amylase
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marker to ID:
acute pancreatitis |
lipase
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marker to ID:
ceruloplasmin |
wilsons
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how to treat hepatic encephalopathy
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lactulose
neomycin |
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what can cause reyes syndrome
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aspirin
virus -VZV -influenza B |
