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228 Cards in this Set

  • Front
  • Back

Esophagus
odynophagia is usually symptom of....
best test...

esophageal ulceration
upper endoscopy
Esophagus
awareness of lump or tightness in throat unrelated to meals or swallowing.
rarely occurs with...

globus sensation
GERD

Esophagus
oropharyngeal dysphagia diagnostic test...


[most effective diagnostic test]

videofluoroscopy

Esophagus
failure of esophageal peristalsis and failure of LES to relax with swallowing....
chest xray finding....
Ba swallow finding....

achalasia
dilated esophagus with air fluid level
bird's beak apperance

Esophagus
diagnosis of achalasia [3 steps]...
treatment...

1. Ba swallow


2. esophageal manometry with esophageal aperistalsis and incomplete relaxation of LES with wet swallows. CONFIRMS DIAGNOSIS


3. EGD to rule out adenoca causing pseudoachalasia
treatment: laparoscopic myotomy

Esophagus
hypermotility esophagus diagnosis...
Ba swallow with corkscew appearance...


treatment...

manometry
diffuse esophageal spasm


calcium channel blocker

Esophagus
most common cuase of infectious esophagitis…


T/F: Need oral thrush to be present for esophageal candidiasis...


C albicans


F: absence of oral candida lesions do not rule out esophageal candiasis.

Esophagus
esophagitis with odynophagia, dysphagia, and sometime restrosternal chest pain

pill induced

Esophagus
patient with seasonal allergies and esophagitis with negative biopsy for GERD...
treatment...


eosinophilic
swallow aerosolized steroids

Esophagus
When to order endoscopy with GERD?

fails empiric therapy

Esophagus
fails antireflux meds and negative EGD...

ambulatory pH monitoring

Esophagus
first line treatment GERD...


refractory reflux confirmed by pH studies or endoscopy or cannot tolerate PPI...


does this decrease risk of adenoca...

PPI


fundoplication


surgery does not reduce risk of cancer

Esophagus
complication of GERD where distal esophagus sq epithelium is replaced by specialized columnar epithelium....
concerning...

Barrett's esophagus
increased risk of esophageal adenoca (premalignant condition)

Esophagus
Diagnosis of Barrett's per histo...


Treatment for minor dysplasia...


Treatment for high grade dysplasia...


Treatment for No dysplasia...

acid mucin containing goblet cells


minor dysplasia - PPI


major dysplasia - endoscopic ablation


serial EGD's

Esophagus
most common malignancy of esophagus...
most common presenting symptom...


What do you do next after biopsy is cancerous...

esophageal ca (sq. cell and adenoca)
progressive solid food dysphagia


STAGING with CT scan, endoscopic US, and PET

Stomach
2 most common causes of PUD…

If young patient WITHOUT alarm symptoms and symptoms of PUD, then...

H pylori infection
NSAIDS

test and treat for H pylori without endoscopy

Stomach
which rebleeds more (ASA + PPI) or plavix...


NSAID related ulcer prophylaxis…


3 complications of PUD [pneumonic]...

plavix


start PPI if receiving chronic NSAID


P - perforation


O - outlet obstruction


B - bleeding

Stomach
stomach discomfort with no physiologic cause…

PUD with FALSE NEGATIVE rapid urease, urea breath test and stool H. pylori...

functional dyspepsia


recent antibiotics, bismuth containing compound or PPI can cause false negative test if not stopped 2 wks before testing

Stomach
PUD, MALT lymphoma, resected gastric cancer, prior PUD without H pylori treatment and dyspepsia WITHOUT alarm symptoms...

diagnostic tests for H. pylori eradication like urea breath test or fecal antigen test

Stomach
H pylori treatment...
why test urease?


If patient returns 9wks after initial treatment for H pylori duodenal ulcer with recurrent symptoms...

10-14 days of 3 meds:
clarithromycin
amoxicillin
twice a day PPI
makes urease to survive acid


recurrent symptoms: urea breath test, if positive then try different antibiotics

Stomach
first line therapy for prophylaxis of NSAID related ulcers…


Duodenal PUD without complications does not require…


Do not order H. pylori Ab assay for eradication testing...

PPI

follow up EGD


Ab assay remains elevated after treatment

Stomach
chronic N/V/early satiety is suspicious for...
treatment and risk factor…

Diagnostic test...

gastroparesis
prokinetic drugs like metoclopramide
1-10% risk of irreversible tar dive dyskinesia.

gastric empty scan. NOT upper GI Ba Xray

Stomach
functional dyspepsia is confusing for....
gastroparesis because it has slow gastric emptying.

Stomach
if you are younger than 40yo, with EGD that shows numerous gastric fundic gland polyps...

need colorectal eval for familial adenomatous polyposis syndrome

Stomach
monitoring for type 1 gastric carcinoid tumor that is small <2cm...

initial removal then endoscope every 6-12mo for 3yrs

Stomach
East asians/chinese are at higher risk for...
gastric adenoca
Stomach
most common risk factor for gastric adenoca
H pylori

Stomach
first sign of anastomotic leak after bariatric surgery in absence of GI bleed...


Diagnosis...


Other bad complication of bariatric surgery...

sustained tachycardia >120


upper GI with oral contrast. extravasated


contrast on imaging reveals need for surgery.


venous thromboembolis, some get IVC filter before surgery

Stomach
confusion, ataxia, nystagmus, opthalmoplegia (paralysis or weakness of eye muscle that controls movement) after BARIATRIC SURGERY...

thiamine defiency (wernicke-Korsakoff)
Pancreas
best imaging test for pancreatitis (when diagnosis uncertain)
CT with contrast

Pancreas
predictor of severe acute pancreatitis...

BUN levels

Pancreas
first treatment for acute pancreatitis
aggressive IVF
Pancreas
when to have ERCP with pancreatitis?
ascending cholangitis
gallstone pancreatitis with worsening LFT's
Pancreas
gallstone pancreatitis without complications
consider GB surgery prior to discharge

Pancreas
most common complication of pancreatitis....
if asymptomatic....

pseudocyst
resolve on their own, no treatment

Pancreas
most common cause of chronic pancreatitis...
independent risk factor for chronic pancreatitis...
etoh
tobacco
Pancreas
abdominal pain with varying degrees of endocrine and exocrine dysfunction…

T/F: normal amylase and lipase RULES out chronic pancreatitis...

chronic pancreatitis

False: normal levels do NOT rule out chronic pancreatitis

Pancreas
treat exocrine dysfunction with chronic pancreatitis...
treat diabetes with chronic pancreatitis…

if young adult with chronic pancreatitis, then test for...

enteric coated pancreatic enzymes with meals
insulin

Cystic fibrosis

Pancreas
risk factors for pancreatic adenoca:
main one
2 factors increase risk 20-fold

age >50
tobacco and chronic pancreatitis

Pancreas
staging pancreatic adenoca (2)

multiplanar CT and endoscopic US (if no mets on CT)

Pancreas
Japanese man with painless obstructive jaundice with sausage shaped pancreas on CT...
has infiltrate rich in...
treatment....

autoimmune pancreatitis (usually in Japan)
lymphoplasmacytic infiltrate with IgG4 cells
steroids

Pancreas
which is more common?
pancreatic cyst vs. malignant cystic neoplasm
20% prevalence pancreatic cyst
1% cystic neoplasm
Pancreas
Diagnosis of cystic lesion

EUS - endoscopic US to aspirate contents of cyst

Pancreas
Pancreatic endocrine tumors are related to: (2)
They arise from...
(most common endocrine tumor)

MEN 1 and von Hippel-Landau disease
islet cells


(gastrinoma)

Pancreas
How to detect insulinoma...

endoscopic US
Diarrhea
stool osmotic gap
4 types
secretory - gap less than 50
osmotic - gap greater than 100
secretory, osmotic, inflammatory, malabsorptive
Diarrhea
acute vs chronic
acute less than 2wks
chronic longer than 4wks

Diarrhea
malabsorption types (4)

celiac
small intestine bacterial overgrowth (SIBO)
short bowel
Lactose malabsorption

Diarrhea
digestive enzymes and intestinal motility is altered causing growth of excess bacteria....
Diagnosis...

SIBO
hydrogen breath test - fermented carbs by SI bacteria

Diarrhea
less than 200cm of remaining small bowel after surgery...


Concern immediately for diarrhea after small bowel resected...

short bowel syndrome


diarrhea from increased gastric acid secretion. Start PPI.

Diarrhea
Diarrhea due to anything that affects small bowel mucosa such as surgery or disease or infection...

lactose malabsorption

Diarrhea
osmotic diarrhea, flatulence, lots of farts. no blood or wt loss....
Diagnosis....

lactose malabsorption
hydrogen breath test >20 ppm

Diarrhea
celiac treatment...


celiac screening test...

avoid gluten


tissue transglutaminase Ig Antibody (tTG)

IBD
mucosal inflammation isolated to colon

UC

IBD
transmural bowel wall inflammation that can affect entire GI tract from mouth to anus

Crohns

IBD
abd pain is rare and is concerning for a complication such as toxic megacolon or perforation....(UC or Chrons)

UC

IBD
painful SC nodules seen on extensor surface of legs seen in IBD...


treatment...

erythema nodosum


increase medical treatment for IBD

IBD
primary sclerosing cholangitis and colorectal ca is usually seen in
UC

IBD
needs complete colonoscopy with inspection of terminal ileum...

UC

IBD
(UC or Crohns) needs EGD and colonoscopy to eval full extent of disease?

Crohns

IBD
IBD flares also test for...
IBD flare that does not respond to steroids...

stool studies for superimposed infections
colonoscopy with biopsy to eval CMV. seen in 30% undergoing colectomy

IBD
Crohns treatment - initiation @ diagnosis...
fails initiation - needing repeat steroids...
fails previous 2 treatments...

5-asa
thiopurine - 6mercaptopurine or azathioprine
anti TNF agents

IBD
UC Treatment - initiation @ diagnosis...
fails initiation....
this med not effective in UC...

5-asa work well (better than crohns)
thiopurine
methotrexate

IBD
UC treatment that fails thiopurine
if all else fails....

anti tumor necrosis factor
colectomy with end ileostomy or jpouch

IBD
normal appearing mucosa but has inflammation on histo. (different from UC and Crohns) causes painless watery diarrhea without bleeding...


diagnostic test...

microscopic colitis


flex sig with MULTIPLE biopsies to catch the pathologic tissue

IBD
microscopic colitis biopsy...
etiology (2)

lots of lymphocytes
med side effect
celiac disease

IBD
acute onset (people remember first episode):
gradually get worse over time:
UC
Crohns
Constipation
recommended fiber intake
25-30g per day
Colon
intestinal syndrome with abdominal discomfort and altered bowel habits without organic cause….
#1 risk factor….
irritable bowel
infectious gastroenteritits
Colon
clinical diagnosis based on Rome 3 criteria...
if no alarm symptoms….
Irritable bowel
no scope

Colon
3 irritable bowel subtypes (D,C,M)

IBS-D - diarrhea
IBS-C - constipation
IBS - M - mixed (alternates diarrhea and constipation)

Colon
test for this if IBS-D or IBS-M...


Treatment for IBS-C, if fails conservative treatment...

celiac disease


lubiprostone

Colon
diagnosis for diverticular disease...

Abd pelvis CT

Colon
1 in 5 patients with ___________ will have one episode of diverticulitis....
3 major symptoms of diverticulitis...


Colonoscopy 5-6wks after treatment is needed to rule out (2)...

diverticulosis
LLQ pain, fever, leukocytosis


rule out crohns or adenoca that mimic diverticulitis

Colon
Which is more common: colonic ischemia or acute mesenteric ischemia...

colonic ischemia

Colon
inadequate blood flow to all or part of small bowel...
Most common cause....

acute mesenteric ischemia
SMA embolus from LA or ventricular mural thrombi

Colon
50yo or older with underlying cardiac disease presents with acute onset severe abd pain with mild belly exam. pain out of proportion for exam...
gold standard diagnosis...

acute mesenteric ischemia
angiography

Colon
treatment for acute mesenteric ischemia...

IVF and antibiotics for possble sepsis
likely will need surgery

Colon
abd pain 30min after eating...
diagnosis...
treatment...

chronic mesenteric ischemia
angiography of splanchnic arteries
surgical revascularization

Colon
acute onset of mild crampy abd pain over affected region of colon…
diagnosis….
imaging result...

colonic ischemia
colonoscopy or flex sig
xray and CT may show thumbprinting

Colon
colonic ischemia sites: (3)
why is rectum spared:
Treatment:

sigmoid and descending colon and watershed areas splenic flexure and rectosigmoid junction.
dual blood supply
supportive care. reverse obvious causes. rarely needs surgery

Colon
most common hereditary colorectal ca...
type of inheritance...


screening colonoscopy start at...

hereditary nonpolyposis colorectal ca
AD


age 20-25

Colon
AD condition with macules in perioral region and buccal mucosa and GI hamartomatous polys in teens/young adults
Peutz Jeghers syndrome
hamartomous - pertaining to a disturbance in growth of a tissue in which the cells of a circumscribed area outstrip those of the surrounding areas.
Colon
4 lifestyle risk factors for colorectal ca
2 conditions that increase risk of colorectal ca
tob, etoh, excess body weight, red meat
DM2, inflammatory bowel

Colon
1 or more adenomas during colorectal screening are at risk for...


if 1-2 adenoma (<1cm) with low grade dysplasia...


if more than 3 adenoma (>1cm) with villous or high grade dysplasia...

advanced colorectal neoplasia. so repeat scope based on polyp findings.


low grade repeat scope in 10yrs


high grade repeat scope in 3 yrs

Colon
patient with colorectal ca that has received curative treatment should be monitored aggressively. why?
detect and prevent recurrence
metachronous colorectal neoplasia
Liver
AST vs ALT. which is rarely outside liver?
ALT - is mostly liver. elevation is more specific for liver disease
Liver
disease of liver: which bilirubin?
conjugated bilirubin - elevated direct
Liver
hemolysis or Gilbert syndrome. which bilirubin?
unconjugated - elevated indirect. defect in bilirubin conjugation

Liver
acute hepatitis duration...
chronic hepatitis duration...

acute less than 6mo
chronic greater than 6mo

Liver
cholestatis labs or abnormalities if flow of bile. (2)
elevated Alk phos and bilirubin.
Hepatitis
diagnosis Hep A...
risk factors: (2)
if exposed to HAV: do this to prevent infection…

Does Hepatitis A cause chronic hepatitis….

anti HAV IgM antibody
sex with men, enteric (dirty hands/food)
prompt vaccination.

DOES NOT CAUSE chronic hepatitis

Hepatitis
Hep B transmission (3)
HBV in adult
HBV in childhood

blood, mucocutanous (sex), perinatal
acute infection then resolution - adult
child can go chronic- can lead to cirrhosis and HCC

Hepatitis
When to treat acute hep B?
When to treat chronic active hep B? (2 occasions)

oral antiviral meds with liver failure. usually self limited.
elevated LFT's or active inflammation on biopsy

Hepatitis
Goal of antiviral hepatitis B treatment…


Avoid this drug treatment for hepatitis if active autoimmune disorders, severe cytopenia, decompensated cirrhosis or major depression...

convert HBsAg + to negative


avoid interferon alfa in those 4 conditions

Hepatitis
review table 28 on pg54

review table 28 on page 54

Hepatitis
Who does not benefit from antiviral treatment for Hep B? (2)

inactive HBV carrier
immune tolerant HBV

Hepatitis
2 extrahepatic manifestations of chronic hep B….
If either are present, then...
polyarteritis nodosa
membranous glomerulonephritis
start viral suppression meds
Hepatitis
Hep C transmission (2)
85% of patients with anti-HCV antibody…

T/F: normal transaminase exclude hep C…


Palpable purpura seen in Hep C...

IVDA or blood transfusion
develop chronic infection

F: normal transaminase occur in up to 40% chronic hep C.


leukocytoclastic vasculitis

Hepatitis
Hep C genotype 1 treatment (3)...
Goal of treatment...

peginterferon and ribavirin and NS3/4A protease inhibitor (boceprevir or telaprevir)
undectable HCV viral levels 6mo after completion of therapy on PCR or SVR sustained virologic response

Hepatitis
incomplete virus that needs Hep B for replication
causes:
diagnosis:
Hep D
severe acute hepatitis
anti HDV antibody
Hepatitis
HDV transmission is similar to:
Once HBV resolves, then:
HBV
HDV resolves
Hepatitis
transmission is similar to HAV (enteric route)
causes acute or chronic hepatitis
diagnosis
Prevention:
HEV
acute hepatitis
IgM antibody to HEV
clean foods and clean hands
Hepatitis
25% Mortality if infected with HEV:
pregnant women in 3rd trimester

Liver
most common cause of acute liver failure requiring transplant in US

drug induced - tylenol

Hepatitis
treatment for severe etoh hepatitis (combo)...


if patient has active infection, GI bleed, pancreatitis or kidney disease then...

corticosteroids or pentoxifylline (improves blood flow)


avoid steroids.

Hepatitis
fatigue, jaundice, and itching with high IgG…

Diagnosis...
Treatment: (1 or combo)

autoimmune hepatitis

liver biopsy
corticosteroids or corticosteroids with azathioprine

Liver
liver disease due to insulin resistance and metabolic syndrome….
treatment…

DIAGNOSIS….


hyper lipid with this condition and elevated aminotransferase...

NAFLD - non alcoholic fatty liver disease
weight loss and treat comorbities

LIVER BIOPSY (not US)


start statin.



Liver
most common genetic disorder in white people...

hereditary hemochromatosis. so screen relatives

Liver
excess iron deposits throughout the body...
but in the liver can cause...
labs: (2)

hereditary hemochromatosis
cirrhosis and HCC
ferritin and transferrin

Liver
hereditary hemochromatosis in patient 40yo or older with ferritin > 1000...


treatment for regular HH…


T/F: nondiagnostic HFE genotype rules out diagnosis of hemochromatosis...

liver biopsy to eval cirrhosis that can develop into HCC


phlebotomy


False: does rule out diagnosis

Liver
accumulation of variant protein inclusion in liver

alpha-1-antitrypsin deficiency
Liver
lung finding for alpha-1-antitrypsin deficiency
panacinar emphysema
Liver
treatment for alpha-1-antitrypsin deficiency with obstructive lung disease
IV alpha-1-antitrypsin

Liver
AR disorder with increased liver uptake of copper and decreased bile excretion of copper...

Wilson

Liver
Wilson disease:
AST and ALT...
anemia type...
Alk phos....

AST, ALT - elevated
hemolytic anemia
alk phos is normal or low due to decreased synthesis

Liver
Wilson disease screening test...
treatment (2)
fulminant wilson disease...

ceruplasmin (usually low)
copper chelating agents (trientine/penicillamine)
transplant or death

Liver
chronic cholestatic liver disease on unknown etiology...

primary biliary cirrhosis

Liver
fatigue, dry eyes, dry mouth, itching...

common symptoms of PBC

Liver
PBC labs:
AST and ALT -
Alk phos -
bilirubin -

AST and ALT elevated
Alk phos elevated
bilirubin normal

Liver
PBC antibody...
PBC histo...

antiMTCH
florid duct lesion - focal duct obliteration with granuloma formation

Liver
PBC treatment...
problem with transplant...

ursodeoxycholic acid
30% of PBC recur

Liver
chronic inflammation of intra and extra hepatic bile ducts....
70-80% have this associated disease...
Diagnosis: (gold standard)

Primary sclerosing cholangitis
inflammatory bowel disease
cholangiography (ERCP)- beads on string where segmental bile duct fibrosis with saccular dilatation

Liver
PSC and ERCP...
ultimate treatment....
major risk of PSC….


If CD4 <100, then...

if PSC is suspected, then order MRCP for diagnosis then ERCP for therapy
liver transplant
cholangiocarcinoma


consider AIDS cholangiopathy due to CMV or Cryptosporidium infection (not PSC)

Liver
most common cause of portal HTN
most common clinic findings of portal HTN (3)
cirrhois
gastricesoph varices
ascites
hepatic encephalopathy

Liver
cirrhosis with no hx of variceal bleed, then screen with:

EGD to exclude large varices

Liver
large esophageal varices prophylaxis:
medication or therapy...


If patient has low HR or asthma....

non selective betablocker (propranolol or


nadolol) or banding


GO to BANDING

Liver
goal resting HR for nonselective betablocker for varices prophylaxis....
recurrent or refractory variceal bleed treatment...

55-60
TIPS - transjugular intrahepatic portosystemic shunt

Liver
large gastric varices with no history of variceal bleed.
nonselective beta blocker and banding are NOT as effective.
endoscopic sclerotherapy is better with followup TIPS

Liver
most frequent complication of portal HTN....

ascites

Liver
SAAG >1.1 and ascites protein is <2.5...

portal HTN is cause of ascites

Liver
SAAG >1.1 and ascites protein >2.5...

cardiac cause

Liver
uncomplicated ascites treatment (1 med and 1 lifestyle)...
moderate to severe ascites...

sodium restriction 2g
diuretics
large volume paracentesis with IV albumin infusion

Liver
refractory ascites that resist conservative treatment (3)

serial paracentesis, TIPS, and liver transplant

Liver
SBP diagnosis (2)...

+ ascites culture
ascites PMN >250

Liver
SBP treatment....


if significant liver/kidney dysfunction....
SBP prophylaxis if recurrent SBP...

3rd generation cephalosporin (cefepime)
albumin
norfloxacin

Liver
hepatic encephalopathy goal of treatment.
should you stop lactulose for diarrhea.
Why is rifaximin helpful?

reduce nitrogen in gut
no, just reduce dose or frequency
reduces bacteria that produce ammonia. use for refractory HE to lactulose

Liver
SBP with renal vasoconstriction that leads to reduction in glomerular functions with minimal histo changes...

hepatorenal syndrome

Liver


hepatorenal syndrome is associated with refractory ascites and less rapid course

Type 2 - not rapid course (ascites)
Type 1 - rapid reduction in kidney function.

Liver
diagnosis of hepatorenal...
treatment....

Cr >1.5 after stopping diuretics and giving volume with ALBUMIN
liver transplant

Liver
defect in arterial oxygenation induced by pulmonary vascular dilatation in setting cirrhosis and portal HTN...

hepatopulm syndrome

Liver
hypoxemic patient with cirrhosis, but no:
COPD, hepatohydrothorax, pulm embolus...

hepatopulmonary syndrome

Liver
Diagnosis for hepatopulm syndrome...
Treatment of HPS with arterial PO2 of 60 or less....

2decho with bubble study and contrast which shows microbubble visualization within L atrium after 3-6 cardiac cycles.
liver transplant (high priority)

Liver
primary portal HTN with pulm HTN...
mild to moderate POPH treatment...
severe POPH treatment....

portopulm HTN
mild to moderate - liver transplant
severe - poor candidate, high surg risk of death

Liver
80% of HCC occurs in...


imaging for diagnosis...
biopsy?...


early stage disease...

cirrhosis of any cause


Abd CT with contrast or MRI with gad


biopsy not necessary if imaging shows HCC, start treatment


early stage - liver transplant

Liver
hepatic ENCEPHALOPATHY in setting of jaundice without preexisting liver disease....
most common cause....
treatment...

FHF- fulminant hepatic failure
acetaminophen toxicity
contact liver transplant center

Liver
elevated LFT or jaundice in absence of evidence of failure of liver function
liver injury

Liver
How to classify liver failure....
treatment for FHF...

# of weeks after jaundice onset that encephalopathy occurs
1 wk is hyperacute and best prognosis for immediate transplant

Liver
FHF with AMS...
treatment...


do not use in...

check intracerebral pressure for cerebral edema
mannitol (NOT steroids)


mannitol is contraindicated in kidney disease

Liver
simple liver cyst on US less than 4cm...

no internal echoic structures, likely asymptomatic

Liver
large cyst that is symptomatic...
concern for symptomatic liver cysts...

laparoscopic fenestration because needle aspiration can cause more cysts. (make opening like window)
could be cystoadenoma that can transform to cystoadenoca which need resection

Liver
benign liver lesion that is hypertrophic tissue reaction to anomalous artery
Focal nodular hyperplasia
Liver
sheets of benign hepatocytes without biliary stricture or other nonparenchymal liver cells, associated with OCP
hepatic adenoma
Liver
hepatic adenoma less than 5cm
larger than 5cm
why treat?
stop OCP
resect
risk of malignant transformation
Liver
Liver lesion if traveled to tropical area with poor santitation
amebiasis

Liver
advanced complication of pre-eclampsia that occurs in 3rd trimester. symptoms are abd pain, N/V, itch, and jaundice....

HELLP - hemolysis, Elevated LFT, Low Platelet)

Liver
HELLP treatment....

manage on high risk OB unit. should improve 4-6 days after delivery. can reoccur in future pregnancies

Liver
other rare liver disease of 3rd trimester...
How is it similar to other pregnancy condition... (2)

AFLP - acute fatty liver of pregnancy
improves after delivery
can recur in future pregnancies

Liver
cirrhosis and bones: test and risk factor
cirrhosis and immunizations
risk for osteoporosis (BMD testing and steroids)
all are ok including hep A and B
Liver
antibiotics to avoid in cirrhosis (2)
augmentin and isoniazid

Liver
hepatic venous outflow tract obstruction including IVC above liver WITHOUT R heart failure or constrictive pericarditis.....


Complication...


Who is @ risk...

Budd chiari
thrombosis
myeloproliferative disorder like PCV

Liver
Budd Chiari diagnosis....
management drug....
contraindicated drug....

obstructed hepatic venous outlfow tract on imaging
start AC
OCP

Liver
symptomatic BCS prognosis and treatment.
fails med management, if fail this then...
will then need lifelong....
poor prognosis
hepatic vein angioplasty +/- stent refractory to AC
TIPS
transplant....AC
Liver
sudden formation of thrombus within portal vein
acute portal vein thrombosis
Liver
fever, sudden abd pain, mesenteric extension, and intestinal ischemia.
PVT (portal vein thrombosis)
Liver
imaging with hyperechoic material in portal vein lumen and tributaries.
treatment.
PVT
AC and surgery to rule out infarction

GB
black gallstones
brown gallstones

black - hemolytic disease and cirrhosis
brown - biliary tract infection
GB
calcified or porcelain GB
higher risk for Ca, so surgery
GB
biliary colic is seen in...
pain longer than 6 hr suggest
symptomatic gallstones
cholecystitis
GB
acute cholecystitis is usually (90%) caused by..
rarely see...
diagnosis..
cystic duct obstruction by gallstone
jaundice
US

GB
If concerned about cholecystitis and US is indeterminate...


HIDA scan

GB
imaging for gallbladder inflammation in absence of obstructive cholelithiasis...
management before surgery...

ABD US to eval acalculous cholecystitis
Abx

GB
leading cause of obstructive jaundice with symptoms of jaundice, belly discomfort, itch, dark urine, pale stools.

choledocholithiasis (CBD stones)

GB
choledocholithiasis imaging (US or noncontrast CT) reveals:
treatment of choice:
followup:
dilation of extrahepatic and intrahepatic bile ducts
ERCP
cholecystectomy within 6wks
GB
If symptomatic choledocholithiasis cannot tolerate surgery
endoscopic sphincterotomy

GB
Fever, jaundice, RUQ pain (Charcot triad)...
treatment...

cholangitis
abx and ERCP (emergent)

GB
if GB is porcelain or large polyp....

take out due to risk for GB cancer, resect polyp

GB
cancer of biliary tree exclusive of GB or ampulla...
major risk factor (2)...

cholangiocarcinoma
primary sclerosing cholangitis and biliary cysts

GB
herditary polyposis syndrome needs regular EGD
monitor for ampullary adenoca
GI
most common type of GI bleed (upper or lower) (defn)
upper GI - intraluminal blood loss proximal to ligament of trietz
GI
most common cause of upper GI bleed (2).
elevated BUN
PUD and esoph varices
upper GI source

GI
vital sign most concerning for severity of bleed (3 in descending order)...

orthostasis > hypotension > tachycardia

GI
management of variceal bleed ASAP (2)...


management of non-variceal bleed...


critically ill patient with upper GI bleed...

abx and octreotide


IV PPI before endoscopy


hemodynamic stability before scope

GI
2 major causes of lower GI bleed

1. diverticula
2. internal hemorrhoids

GI
most lower GI bleeds stop...

without intervention, but early rebleeding is common

GI
recurrent GI bleed without defined source after EGD/colonoscopy....
what should you do first?


Do not order this test...

obscure GI bleed
repeat EGD/colonoscopy

do not order small bowel X-ray

GI
Obscure GI bleed that is ACTIVE after failed repeat EGD/colonoscopy:


if bleeding is light...


if bleeding is heavy...

angiography for heavy bleeding


technetium labeled nuclear scan for light bleeding

Liver


cirrhotic with complication of ascites, hepatic encaphalopathy, jaundice, or portal HTN related bleeding...


treatment...

decompensated cirrhosis


liver transplant

IBD


UC with spread beyond rectum and Crohns with more than 1/3 colon involved are at risk for...


screening...


if UC only effects rectum (proctitis only)...

colorectal ca


colonoscopy 1-2yrs with biopsy


10yr for UC proctitis

Liver


pregnant presents with itch and elevated bilirubin...


treatment…


First sign of fetal distress...

intrahepatic cholestasis of pregnancy


ursodeoxycholic acid


deliver baby

GI


non-variceal upper GI bleed with INR 2.8...

can go to EGD, do not have to reverse AC if INR<3

GI


15-20% of BRBPR come from this source...


why is this concerning...


What happens if NG tube is negative for blood or coffee ground emesis....

upper GI bleed


may be heavy bleed of at least 1L causing syncope and presyncope


NG tube placement can yield false negative.

IBD


treatment for severe Crohns with wt loss and significant inflammation on colonoscopy...

anti TNF alpha like infliximab

GI


EGD of bleeding ulcer reveals active arterial spurting or nonbleeding visible vessel in ulcer base requires this post procedure....

72hr observation in the hospital due to risk of rebleed

GI


aortic stenosis patient with bleeding angioectasia...


treatment...

Heyde syndrome


AV replacement

Cancer


Familial Adenomatous Polyposis after complete colectomy...

check EGD to eval duodenal/ampullary cancer

Ascites


first step of workup for ascites...


uncomplicated ascites treatment (combo)...

check SAAG.


if >1.1 and ascites protein <2.5 then portal HTN.


if >1.1 and ascites protein >2.5, then cardiac cause.


reduce salt in diet and diuretics

IBD


UC or Crohns flare: check this...

C. diff to rule out superimposed infections. do not need recent abx usage to be at risk.

IBD


immunocompromised with IBD must avoid these vaccines...

live vaccine like VZV, nasal flu, MMR

Colon ca


if age 50yo and have only 1 of 6 + fecal occult blood...

go to colonoscopy. only need 1 positive test.

Hepatitis


When to start treatment on hep C...

when significant fibrosis is present. start ribaviron and interferon

Esophagitis


Treatment for HSV esophagitis...


Treatment for CMV esophagitis...

HSV - acyclovir


CMV - ganciclovir

Colon


42yo with 3mo history of worsening constipation with occasional blood in stool...

colonoscopy due to worsening constipation.

IBD


Crohns treatment for perianal disease after successful surgery and NO signs of active infection...

anti-TNF agent

Diarrhea


Diarrhea with low B12 and high folate...

SIBO - bacteria consume B12 but produce folate

Hepatitis


Hepatitis B immune tolerant has high....


these labs are normal...


when should be concerned...

high viral load


LFT's are WNL


when LFT's are elevated which is concerning for active hepatitis. check biopsy

PUD


melena with scope that reveals that is negative for H. pylori by urease, histo, or culture...

check H. pylori serology because recent GI bleed and PPI can affect other tests for H. pylori (serology is not affected)

PUD


patient with no risk factors or alarm symptoms but chronic dyspepsia for 1 yr from developing country...


if from developed country...

test and treat approach for H. pylori


start PPI if not from H. pylori area

Stomach


patient who smokes marijuana that has cyclic N/V...


N/V improves with this activity...

cannabinoid hyperemesis syndrome


hot bath

Biliary Tree


dilation of bile duct without obstructing lesion that presents with abdominal pain with recurrent cholangitis or jaundice...


what is risk...

biliary cyst


cyst can lead to cholangiocarcinoma, so cut out the cyst

Liver


young person with fulminant liver failure...

rule out Wilson disease

Esophagus


treatment for patient with BOTH eosinophilic esophagitis and gerd...

start PPI first. if it fails than aersolized steroid. eosinophilic may be due to gerd, so rule out gerd first with PPI trial or ambulatory pH study

GB


elderly with low BP, tachycardia, tachypnea, elevated LFT's....

cholangitis,so get ERCP.


it seen more with elderly with DM2. they may not have fever or leukocytosis

Colon


Consider this test and condition if iron def anemia with negative EGD and colonscopy...

repeat scopes with more biopsies to test tissue transglutaminase Ab (tTG) to eval celiac disease

Colon


microscopic colitis caused by NSAIDs or lansoprazole, treatment...

stop offending meds first (NSAIDs or lansoprazole)

Celiac Disease


definitive diagnosis…


Why avoid gluten free diet for empiric therapy…


Most common reason for failure of treatment...

small bowel biopsy or presence of dermatitis herpetiformis


false negative serology testing. can't confirm diagnosis


nonadherence to diet

Celiac Disease


Adhere to gluten free diet but still suffer recurrent malabsorption...

eval intestinal lymphoma

Malabsorption


4 most common disorders…



celiac disease


small bowel bacterial overgrowth


short bowel syndrome


pancreatic insuff

Malabsorption


avoid this drug if ileal resection >100cm..

cholestryramine will worsen bile salt def and steatorrhea

Liver


Elevated indirect or unconjugated bilirubin with normal ALT and AST and NO hemolysis with normal Hgb and retic count….


Extensive workup...

Gilbert


No extensive workup

Gallstone


Treatment for acute cholecystitis within 24-48hr…


Avoid this treatment for acute cholangitis...

surgery


avoid surgery due to increased mortality. do ERCP.

Gallstone

gallstone becomes impacted in the cystic duct or neck of the gallbladder causing compression of the common bile duct (CBD) or common hepatic duct, resulting in obstruction and jaundice (elevated bilirubin)…

treatment...

Mirizzi syndrome


cholecystectomy

Cirrhosis


active variceal bleed that fails octreotide and banding…


diuretic refractory ascites that fails large volume paracentesis….


complication of this procedure...

TIPS - transjugular intrahepatic portosystemic shunt


portosystemic encephalopathy (if shunt is too big where too much portal blood goes to hepatic circulation)

IBS


older than 50yo with severe or refractory symptoms of irritable bowel…


Avoid this medication to treat IBS...

colonoscopy


alosetron can cause ischemic colitis

IBD


avoid this procedure with moderate to severe UC which can cause toxic megacolon…


complication of Crohn disease and cystitis...



Barium enema


enterovesical fistula

IBD


If dysplasia is found in UC or Crohns on screening colonoscopy...

proctocolectomy

Upper GI bleed


avoid this test which may interfere with subsequent endoscopy or other study…


These 2 labs are unreliable indicators of volume and should not be used for determination of volume replacement...

Ba xray


Hgb and HcT are unreliable for indicator for volume in upper GI bleed

Upper GI bleed


this medication is not helpful in managing upper GI bleed...

H2 blocker