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30 Cards in this Set

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Aminosalicylates:
1. Sulfasalazine (AZULFIDINE)
2. Olsalazine (Dipentum)
3. Balasazide (colazal)
4. 5-Aminosalicylic Acid (MESALAMINE)
Sulfasalazine:
- 20-30% orally admin.
- Sulfapyridine is absorbed from the colon, and undergoes extensive metabolism
Sulfasalazine A.E:
Malaise, GI Problems, HA, arthralgia, alopecia.
Mesalamine:
5-ASA prep. designed to deliver different seg of the small and large intestine.
Pentasa:
time- release microgranules taht release 5-ASA through out small intestine
Asacol:
5-ASA coated in pH sensitive resin-dissolves at pH 7
Rowasa:
Enema formulations
Canasa:
suppositories.
Glucocorticoids:
1. predisone
2. prednisolone
inhibit production of cytokines (TNF - alpha, IL-1)
INHIBIT gene transcription
Purine Analogs:
6-MP (6-mercaptopurine, PURINETHOL)
Azathiopine
Azathiopine prodrug for 6-MP.
INHIBITION of purine nucleotide metabolism and DNA synthesis and repair -- inhibition of cell proliferation and division
MONITORING REQUIRED FOR PURINE:
1. BLOOD, LIVER, AND PANCREATIC FUNCTIONS REQ.
A.E. OF PURINE
bone marrow depression, pancreatitis, hepatotoxicity, fever, rash, abdominal pain.
Balsalazide increases:
Allopurinol increases:
6-MP levels
azathioprine.
Methotrexate:
cytotoxic agents w/ immune-suppressive and antiinflammatory prop.
inhibitor of dihydrofolate reductase
Methotrexate A.E.:
Bone Marrow Depression
Stomatitis
Hepatotoxicity
Infliximab (REMICADE)
25% MOUSE AND 75% HUMAN (chimeric monoclonal antibody that binds to and neutralizes the activity of TNF - alpha)
Side effects of Infliximab:
1. AVOID in CHF.
2. Delayed hypersensitivity
3. Upper respiratory tract infections.
Mild to moderate Crohn's Disease
Cipro, and metronidazole
Antiemetic Drugs
5-HT3 receptor antagonist
Dopamine antagonists
Histamine H1 receptor antagonists
Antimuscarinic
Cannabinoid
Corticosteriods
Benzodiapines
Substance P Antagonist
5 HT3 ANTAGONISTS
Ondasetron (Zofran)
Dolasetron (Anzemet)
Granisetron (Kytril)
Palonosetron (Aloxi)
Dolasetron metabolized in plasma to:
Active metabolite: hydroxydolasteron
Ondasetron, Palonosetron, granisetron metabolized
liver
Palonosetron Caution with
Prolonged QT interval.
Dopamine receptor antagonist:
D2 RECEPTOR ANTAGONZISM IN ctz.
Prochlorperazine (COMPAZINE)
Chlorpromazine
Thiethylperazine (TORECAN)
Histamine H1 receptor antagonists:

ae. antichol.
CYCLIZINE (MERIZINE)
MECLIZINE (BONINE)
DIPHENHYRDRAMINE (BENEDRIL)
DIPHENYDRINATE (DRAMMAMINE)
PROMETHAZINE
Anticholinegic Agent(Muscarinic receptor antagonist) CONTRAINDICATION:
Scopolamine:
GLAUCOMA.
Cannabinoid
Dronabinol (MARINOL): synthesized from marijuana plant.
Dronabinol:
can stimulate appetite and can be used in pts w/ anorexia from AIDS
Benzodiazepines:
Lorazepam
Alprazolam
Substance P Antagonist
Aprepitant (Emend):
1. Neurotransmitter
2. Polypeptide