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30 Cards in this Set
- Front
- Back
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Aminosalicylates:
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1. Sulfasalazine (AZULFIDINE)
2. Olsalazine (Dipentum) 3. Balasazide (colazal) 4. 5-Aminosalicylic Acid (MESALAMINE) |
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Sulfasalazine:
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- 20-30% orally admin.
- Sulfapyridine is absorbed from the colon, and undergoes extensive metabolism |
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Sulfasalazine A.E:
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Malaise, GI Problems, HA, arthralgia, alopecia.
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Mesalamine:
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5-ASA prep. designed to deliver different seg of the small and large intestine.
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Pentasa:
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time- release microgranules taht release 5-ASA through out small intestine
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Asacol:
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5-ASA coated in pH sensitive resin-dissolves at pH 7
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Rowasa:
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Enema formulations
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Canasa:
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suppositories.
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Glucocorticoids:
1. predisone 2. prednisolone |
inhibit production of cytokines (TNF - alpha, IL-1)
INHIBIT gene transcription |
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Purine Analogs:
6-MP (6-mercaptopurine, PURINETHOL) Azathiopine |
Azathiopine prodrug for 6-MP.
INHIBITION of purine nucleotide metabolism and DNA synthesis and repair -- inhibition of cell proliferation and division |
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MONITORING REQUIRED FOR PURINE:
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1. BLOOD, LIVER, AND PANCREATIC FUNCTIONS REQ.
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A.E. OF PURINE
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bone marrow depression, pancreatitis, hepatotoxicity, fever, rash, abdominal pain.
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Balsalazide increases:
Allopurinol increases: |
6-MP levels
azathioprine. |
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Methotrexate:
cytotoxic agents w/ immune-suppressive and antiinflammatory prop. |
inhibitor of dihydrofolate reductase
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Methotrexate A.E.:
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Bone Marrow Depression
Stomatitis Hepatotoxicity |
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Infliximab (REMICADE)
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25% MOUSE AND 75% HUMAN (chimeric monoclonal antibody that binds to and neutralizes the activity of TNF - alpha)
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Side effects of Infliximab:
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1. AVOID in CHF.
2. Delayed hypersensitivity 3. Upper respiratory tract infections. |
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Mild to moderate Crohn's Disease
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Cipro, and metronidazole
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Antiemetic Drugs
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5-HT3 receptor antagonist
Dopamine antagonists Histamine H1 receptor antagonists Antimuscarinic Cannabinoid Corticosteriods Benzodiapines Substance P Antagonist |
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5 HT3 ANTAGONISTS
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Ondasetron (Zofran)
Dolasetron (Anzemet) Granisetron (Kytril) Palonosetron (Aloxi) |
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Dolasetron metabolized in plasma to:
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Active metabolite: hydroxydolasteron
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Ondasetron, Palonosetron, granisetron metabolized
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liver
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Palonosetron Caution with
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Prolonged QT interval.
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Dopamine receptor antagonist:
D2 RECEPTOR ANTAGONZISM IN ctz. |
Prochlorperazine (COMPAZINE)
Chlorpromazine Thiethylperazine (TORECAN) |
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Histamine H1 receptor antagonists:
ae. antichol. |
CYCLIZINE (MERIZINE)
MECLIZINE (BONINE) DIPHENHYRDRAMINE (BENEDRIL) DIPHENYDRINATE (DRAMMAMINE) PROMETHAZINE |
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Anticholinegic Agent(Muscarinic receptor antagonist) CONTRAINDICATION:
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Scopolamine:
GLAUCOMA. |
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Cannabinoid
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Dronabinol (MARINOL): synthesized from marijuana plant.
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Dronabinol:
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can stimulate appetite and can be used in pts w/ anorexia from AIDS
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Benzodiazepines:
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Lorazepam
Alprazolam |
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Substance P Antagonist
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Aprepitant (Emend):
1. Neurotransmitter 2. Polypeptide |
