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9 Cards in this Set
- Front
- Back
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Which cells secrete Secretin, what is it secreted in response to and what is it's function?
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Secreted by S cells in duodenum in response to increased acid and fat. Causes secretion of bicarb by Brenner's glands, decreased gastric acid, and secretion of bile.
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Which cells secrete CCK, what is it secreted in response to and what is it's function?
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Secreted by I cells in duodenum and jejunum in response to FAs and AAs. Causes increased pancreatic enzyme secretion and gallbladder contraction.
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Which cells secrete gastrin, what is it secreted in response to and what is it's function?
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Secreted by G cells in the stomach antrum in response to stomach distension, peptides, & vagal stim. Increases H+ secretion by parietal cells, stimulates growth of gastric mucosa, & increases gastric motility.
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Which cells secrete VIP, what is it secreted in response to and what is it's function?
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Secreted by the pancreas? in response to distension & vagal stim. Decreased by adrenergic input. Functions to increase intestinal water & electrolyte secretion, & relax intestinal sm muscle & sphincters.
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Which cells secrete motilin, what is it secreted in response to and what is it's function?
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Produced in the small intestine in fasting state. Serves to increase intestinal motility
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Which cells secrete somatostatin, what is it secreted in response to and what is it's function?
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Secreted by D cells in pancreas & GI mucosa in response to low pH. Secretion decreased by vagal stim. Functions centrally to inhibit GH & TSH release as well as suppresses release of most other GI hrmnes.
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What is the mechanism of EHEC's toxin?
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Shiga-like AB toxin. B toxin facilitates entry into cells and A portion prevents t-RNA from binding to 60s
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What is the mechanism of ETEC's toxin?
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Same as V. cholerae, increases intracellular cAMP causing fluid efflux from cells
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What is the mechanism of C. diff's toxin?
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2 toxins A & B, Toxin B depolymerizes actin filaments
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