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50 Cards in this Set
- Front
- Back
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what are the 2 general types of viral hepatitis and route of infection? types of hepatitis associated with?
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Infectious (fecal oral) [A]
Serum (blood) [B and D] |
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how is hep E transmitted?
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Enterically
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how is hep C transmitted?
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Parenterally
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Source of hep A?
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Feces
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Rout of transmission for hep A?
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fecal-oral
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Hep A: chronic infection?
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No
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Hep A: prevention?
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Immunization
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Treatment for hep A
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IgG
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prognosis for hep A
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excellent
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Source of hep B?
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Blood/blood-derived/body fluids
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route of transmission for hep B
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Percutaneous/mucosal/sexua
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hep b: chronic infection?
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yes (esp infants)
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hep B: prevention?
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immunization
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Treatment for hep B?
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IF/RTI
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Prognosis for hep B?
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If chronic, variable outcome
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source of hep C?
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Blood/blood-derived/body fluids
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route of transmission of hep C?
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Percutaneous/mucosal/sexual
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hep C: chronic infection?
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yes
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prevention of Hep C?
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blood donor screening, risk behavior modification
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Tx for hep C?
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IF/Ribavirin
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prognosis for hep C
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If chronic, variable outcome
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Source of hep D?
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Blood/blood-derived/body fluids
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route of transmission for hep D
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Percutaneous/mucosal/sexual
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hep D: chronic infection?
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yes
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hep D: Prevention
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immunization
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tx for hep D?
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IF/RTI
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prognosis for hep D?
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If chronic, variable outcome
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source of virus for hep E?
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feces
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route of transmission for hep E?
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fecal-oral
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hep E: chronic infection?
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no
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prevention of getting hep E?
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ensure drinking water
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tx for hep E?
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none
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prognosis for hep E
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good
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what initiates most of the symptoms of hepatitis?
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immune response, leads to liver damage gastroenteritis, etc.
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in Hep A, who gets worse jaundice, kids or adults?
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ADULTS
due to having a stronger and faster immune response (remember it was the immune response that lead to the symptoms of hep) |
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hep A infection is more common in adults or kids?
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kids
(rash may occur) |
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Mortality due to this virus is low, no chronicity, and there are no second attacks...what is it?
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Hep A
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this virus is most commonly found in kids, it is transmitted fecal-oral route (person-person), food, and water. It can cause small outbreaks at banquets
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Hep A
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in this virus, the outer surface antigen (the "Australia" antigen) is outer capsid and appears in large quantities in the blood
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Hep B
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What is the outer capsid of Hep B called?
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Hbs-Antigen, the Australia antigen
shows up in large quantities in the blood |
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what can you use to diagnose Hep B? 4
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Hbs (outer capsule)
HBc antigen (inner capsid)- only in hepatocyes HBe-antigen (non-structural but detected in blood)-sits btw outer and inner capsid (only appears if there is live infectious virus in the blood) Hbx gene- inhibitor of p53; also inhibits GSK-3b tumor suppressor. May promote oncogene activation |
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for hep B, this antigen only appears if there is live infectious virus in the blood...
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HBe-antigen
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this hepatitis has a long incubation period (30-180 days), higher risk or mortality, and the recovery is prolonged, and can develop into a chronic carrier state
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Hep B
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what can lead to progression to chronic Hep B
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delayed immune response to HBs and HBe
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Energix-B, Recombivax HB are what?
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vaccines for Hep B
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what increases the severity of Hep B and likelihood of fulminant hep, chronicity?
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Hep D
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quasispecies, aka small antigenic changes all the time (drift) is seen in what hepatitis?
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Hep C
Mutant swarm |
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HCV + alcohol abuse can likely lead to what problem?
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Cirrhosis
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Leading worldwide cause of waterborne hepatitis?
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Hep E
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this has the same effects of Hep A but comes from the water
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Hep E
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