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9 Cards in this Set
- Front
- Back
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Describe When Radiation effects a fetus and how
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prior to 8 wks miscarriage, 8-15 dose dependent
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Alcohol, when and how it affects fetus
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more than 2oz/day in the first trimester = fetal alcohol synd.
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Anticonvulsants - dilantin or valproic acid
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to reduce risk of effect, take folic acid 2-3 mo before preg.
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Maternal Diabetes - type I insulin dependant,
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first trimester during organogenesis = malformation
, so want to control diabetes before preg third trimester = macrosomia(large size) |
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Timeline of formation in the fetus,
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Wk 3-8 period of greatest sensititvity with each organ system
9-38 weeks, period of functional maturation Wk 3: heart Wk 4-6.5: Heart upper/lower limb, eyes, ears Wk6.5-8: heart, upper/lowerlimbs, eyes teeth, palate, genitals, ears Wk 8-9: eyes teeth palate genitals ears Wk 9-16: eyes teeth genitals ears Wk 16-end: eyes teeth genitals CNS: Throughout Heart: wk3-8 UpperLimbs: wk 4-9 Eyes: 4.5 - end lowerlimbs - 4-8 Teeth: 6-end Palate: 6.5-9 Genitals: 7.5 to end Ears: 4-20 |
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PKU during preg
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Dose relationship b/w mom phenylal levels and microcephaly/ congenital heart disease
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Systemic lupus erythematosus
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Increase risk of miscarriage
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Characteristics of teratogens likely to gain access to the fetus
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Low MW, Fat soluble, polar stereospecificity, functional groups, low affinity for plasma proteins
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Things to ask for when taking a teratogenic history
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Prescription and over the counter meds, occupational history of chemical exposure, travel, radiation history, anesthesia, Maternal familial and consanguinity history
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