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6 Cards in this Set

  • Front
  • Back
patients with leukemia given 6-mercaptopurine azathioprine will develop CNS tumors if they are deficient in what enzyme
Thiopurine Methyltransferase
phase I-drug metabolism
breaking drug down
phase II-drug metabolism
polarizing drug for excretion
Number of copies of CYP2-D6 (cytocrome 450 2D6) genes expressed coorelates with ___________ drug metabolism
P- glycoproteins
pumps on epithelial cells that keep drugs from being absorbed
e.g., blood brain barrier
The genetic constitution of an individual with respect to one member of a pair of allelic genes; individuals are of the same haplotype (but of different genotypes) if alike with respect to one allele of a pair but different with respect to the other allele of a pair.