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6 Cards in this Set
- Front
- Back
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patients with leukemia given 6-mercaptopurine azathioprine will develop CNS tumors if they are deficient in what enzyme
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Thiopurine Methyltransferase
(TPMT) |
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phase I-drug metabolism
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breaking drug down
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phase II-drug metabolism
-TPMP |
polarizing drug for excretion
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Number of copies of CYP2-D6 (cytocrome 450 2D6) genes expressed coorelates with ___________ drug metabolism
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increased
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P- glycoproteins
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pumps on epithelial cells that keep drugs from being absorbed
e.g., blood brain barrier |
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haplotype
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The genetic constitution of an individual with respect to one member of a pair of allelic genes; individuals are of the same haplotype (but of different genotypes) if alike with respect to one allele of a pair but different with respect to the other allele of a pair.
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