Genetics Muscle Weakness Population Genetics

Front 1

define and be able to calc p/p/p^2/q^2/2pq
factors affecting hardy weinberg
explain why a particular genetic disorder could be more common in one pop than another

Back 1

overview

Front 2

Hardy Weinberg
defines relationship between?

Back 2

relationship between gene frequency and genotype frequency in a pop

Front 3

assumptions of hardy weinberg
(eqn's)

Back 3

p = A
q = a
p+q = 1
p^2 + 2pq + Q^2 = 1

Front 4

factors affecting the HW equilibrium

Back 4

non-random mating
selection
mutation
small pop size can cause genetic drift

Front 5

non-random mating

Back 5

stratification (irish african hispanics etc)
asssortative mating (look a like)
consanguinity

Front 6

negative selection
heterozygote advantage

Back 6

mutation leads to loss of fitness

you know

Front 7

mutations

Back 7

HW principle assumes no new mutations

in real life if have HW concerning mutations it means that the rate of mutations is equal to the loss of the allel due to decreased fitness

Front 8

gene flow

Back 8

the slow diffusion of alleles throughout the world

Front 9

coefficient of Inbreeding

Back 9

F - common genetic ancestor, proba of inheriting the same allele

Front 10

founder effect

Back 10

small group breaks off from larger colony by chance, carry abnormal alleles, or abnormally small amount of mutations