Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
9 Cards in this Set
- Front
- Back
|
Help proteins fold properly
|
Chapterones
Ie: heat shock proteins help refold proteins that have been damaged by high T |
|
|
proteins can be cleaved into multiple active proteins
Can make many products even though have 1 ORF |
polyproteins
|
|
|
O-linked glycosylation
|
-Sugar is put on OH groups of Ser & Thr
|
|
|
N-linked glycosylation
|
-Glycolipid Dolichol P added in ER
-in Golgi, some mannose is cut-out & terminal specific sugars added |
|
|
Signal peptide
|
First 20 aa carry "signal" for hydrophobicity
|
|
|
Signal Recognition Particle
|
Binds to signal peptide while still attached to mRNA/ribosomes & docks on RER membrane
|
|
|
Co-translational transport
|
As ribosome is translating protein it pushes thru ER membrane because of hydrophobicity
|
|
|
Signal peptidase
|
Signal peptide cleaved off in the lumen
So protein is now OUTSIDE cell |
|
|
How are integral membrane proteins made?
|
At the end of t/sc:
Protein in ER, partially in ER membrane, partially in cytosol mRNA codes for a "stop transfer" signal which is very HYDROPHILIC aa which will not go through the membrane |
