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46 Cards in this Set
- Front
- Back
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CML
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t(9;22) - BCR/ABL
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B-precursor ALL
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Hyperdiploidy > 54 chromosomes - Good prognosis
t(12;21) -TEL/AML1 - Good prognosis t(4;11) - MLL - Poor prognosis (Biphenotypic) t(1;19) Poor prognosis t(9;22) - BCR/ABL Poor prognosis |
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Burkitt;s
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t(8;14) - cMyc/IgH
t(8;22) - cMyc/IgK t(2;8) - cMyc/IgL |
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Follicular
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t(14;18) -BCL2/IgH
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AML (M2)
Myeloblastic with differentiation |
t(8;21) -ETO/AML1
-good prognosis |
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AML (M3)
Promyelocytic |
t(15;17) -PML/RARA
-responds to ATRA -DIC |
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AML (M4 with eos)
Myelomonocytic with eosinophilia |
inv (16) - -CBFB/MYHII
t(16;16) -good prognosis -CNS infiltration |
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AML (M5)
Monoblastic |
t(9;11)
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AML
-post-topoisomerase II therapy |
11q23 MLL
-poor prognosis |
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AML (M7)
Infantile |
t(1;22) OTT/MAL
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MDS 5q-
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-elderly women with macrocytic anemia and thrombocytosis
-good prognosis |
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Mantle cell lymphoma
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t(11:14) BCL1/IgH
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MALT
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t(11:18) MLT/API2
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Which B-precursor ALL molecular defects have a good prognosis?
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-Hyperdiploidy > 54 chromosomes
-t(12;21) TEL/AMLI |
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Which B-precursor ALL molecular defects have a poor prognosis?
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t(4;11) MLL
t(1;19) t(9;22) BCR/ABL |
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Myeloma
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Hyperdiploidy - Good Prognosis
t(11;14) CCNDI/IgH -Most common t(8;14) cMyc/IgH Poor Prognosis Del 13 Poor Prognosis t(4;14) Poor Prognosis t(14:16) Poor Prognosis |
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Anaplastic large cell lymphoma
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t(2;5) ALK/NPM Good prognosis
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Ewing/PNET
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t(11;22) FLI1/EWS
t(21;22) ERG/EWS |
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Neuroblastoma
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del(1p), +17 nMyc
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Alveolar rhabdomyosarcoma
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t(2;13) PAX3/FKHR
t(1:13) PAX7/FKHR |
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Desmoplastic Small Round Blue Cell Tumor
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t(11;22) EWS/WT1
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Alveolar soft part sarcoma
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t(X;17) ASPL/TFE3
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Dermatofibroblastoma protuberans
Giant cell fibroblastoma |
t(17;22) COL1A1/PDGF
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Infantile fibrosarcoma
Congenital mesoblastic nephroma |
t(12;15) ETV6/NTRK3
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Myxoid chondrosarcoma
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t(9;22) CHN/EWS
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Lipsarcoma
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t(12;16) FUS/CHOP
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Clear cell sarcoma
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t(12;22) ATF1/EWS
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Synovial Sarcoma
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t(X;18) SSX1/SYT (biphasic)
SSX2/SYT (monophasic) |
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Oligodendrioglioma
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del 1p
del 19q -more responsive to treatment |
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Meningioma
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del 22q NF2
-del 1p or 14q ------ ANAPLASTIC |
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Clear cell RCC
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del(3p)
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Papillary RCC
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Loss of Y, +7, +17, t(x;1)
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Translocation RCC
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t(X;17) ASPSCR1/TFE3
t(X;1) PRCC/TFE3 |
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What translocations are associated with CBF-alpha/beta?
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t(8:21) ETO/AML
inv(16) CBFB t(12;21) TEL/AML1 |
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In ALL, which translocations have a good prognosis?
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Hyperdiploidy >50%
t(12;21) TEL/AML1 -25% of all ALL's -have to do FISH or RT-PCR *regular cytogenetics will not pick up |
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In ALL, which translocations hae a bad prognosis?
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hypodiploidy
t(9;22) t(1;19) t(4;11) t(8:14) |
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In CML, what cytogenetic abnormalities predict evolution?
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+Ph
iso17q +8 |
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In MDS, what are the numeric cytogenetic abnormalities?
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-5
5q- -7 7q- +8 20q- -Y |
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In MDS, what are the translocations?
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t(1;7)
t(5;12) t(1;3) t(2;11) |
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Low grade fibromyxoid sarcoma
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t(7;16)
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Alveolar rhabdomyosarcoma
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t(1;13) pax3;fkhr
t(2;13) pax7; fkhr -poor prognosis, whereas ebmryonal has good prognosis |
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follicular papillary thyroid
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t(2;3) pax8-ppar
-40 of papillary throid ca's with overt ivasvular invasion |
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seminoma
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i(12p)
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liposarcoma
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ring chrom 12
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DFSP
Giant cell fibroblastoma Bednar Tumor |
t(17;22) COL1A1-PFFB
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Endometrial stromal sarcoma
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t(7;17) JAZF1-JJAF1
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