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9 Cards in this Set
- Front
- Back
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CYP3A4
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-drug metabolism
inhibited by: grapefruit juice, corn induced by: flavone, tangeretin |
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CYP1A2
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-drug metabolism
inhibited by: coffee, corn induced by: chili peppers, beef |
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CYP2D6
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-drug metabolism
inhibited by: water cress subtrates = antipsychotics, antidepressants, cardiovascular agents, opiates slow metabolizer variant: African-Americans, Asian, Nicaraguan, Tanzanian, Mexican-Americans super extensive variant: Ethiopians, Saudi Arabians, Spaniards, some Caucasians |
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CYP2E1
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-alcohol metabolism
inhibited by: water cress induced by: ETOH, acetominophen |
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poor metabolizer
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has low enzyme
will get side effects at low doses |
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extensive metabolizer
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normal
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slow metabolizer
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has slow enzyme
will get side effects at normal doses (African-Americans, Asian, Nicaraguan, Tanzanian, Mexican-American have slow metabolizing variant of CYP2D6) |
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super extensive
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has fast enzyme
will have no response at normal levels (Ethiopians, Saudi Arabians, Spaniards, some Caucasians have super extensive variant of CYP2D6) |
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CYP2C19
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-drug metabolism
for poor metabolizing variant: Asians > African-Americans > Caucasian and Hispanic |
