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7 Cards in this Set
- Front
- Back
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Genetic disease |
Can be caused by abnormality of 1 or more genes and can be: -inherited (according to mendelian principles) -new mutation and then inherited (Chromosome abnormalities are raely inheritable) |
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Single gene disorders |
-autosomal dominant -autosomal recessive -sex-linked |
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Polygenic disorders |
Many traits are determined by combined action of several genes at different loci e.g. hair and eye colour. |
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Autosomal dominant |
-All heterozygote offspring are affected -affects all generations -m/f equally - homozygote offspring affected are rare but are worse thsn heterozygotes. |
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Single gene disorder with recessive inheritance |
-Requires both parents to carry abnormal gene. -M/f equally -skips generations |
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X-linked recessive Inheritance |
-gene is on X chromosome -males have 50% of being carriers and woman are normally carriers |
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Chromosome abnormalities |
Polypoid(multiples of 23 (not 46) Aneuploidy (chromosomes gained or lost: trisomy (chromosome increased) or monosomy (chromosome decreased) |
