Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
11 Cards in this Set
- Front
- Back
|
ABL
|
Chronic myeloid leukemia
Oncogene Kinase of signaling pathway |
|
|
MYC
|
Neuroblastoma
Oncogene Transcription factor |
|
|
RAS
|
Colorectal cancer and more
Oncogene Intracellular signalling |
|
|
RB
|
Retinoblastoma
Tumor suppressor gene Regulates cell cycle by inhibiting cell division. Both copies of the gene must be mutated to allow unregulated growth. "Two hit" hypothesis. Be sure to check for Ocular Larva Migrans (OLM) infection with Toxocara canis (dog worm) before enucleation. |
|
|
TP53
|
Lung cancer
Tumor suppressor gene Regulates cell division and apoptosis |
|
|
MLH1, MSH2
|
Colorectal cancer
Caretaker gene DNA repair |
|
|
BRCA1/2
|
Breast cancer
Caretaker gene DNA repair |
|
|
p53
|
Wide variety of cancers
Tumor suppressor gene Li Fraumeni Syndrome |
|
|
WT
|
Tumor of the kidneys
Tumor suppressor gene Wilms tumor |
|
|
APC
|
Familial Adenomatous Polyposis
Many, many colon polyps Truncated protein results in non-functional APC protein. |
|
|
HNPCC
|
Hereditary non-polyposis colon cancer
MSH2 - chromosome 2 MLH1 - chromosome 3 microsatellite instability |
