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12 Cards in this Set
- Front
- Back
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BRCA1 |
HBOC syndrome Breast 87% increased lifetime risk. 7% of all breast cancers. |
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BRCA2 |
HBOC syndrome Ovarian 63% increased lifetime risk 11-15% of ovarian cancer. Prostrate Cancer increased risk Pancreatic cancer increased risk Male Breast cancer increased Possibly Melanoma possible increase. |
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MSH2 |
Endometrial Cancer 15-60% increased risk by 70 |
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PMS2 GENE |
CRC COLORECTAL increased risk up to 20% by 70. |
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PMS2 Gene |
Endometrial Cancer increased risk up to 15% by 70 |
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APC |
Familial Adenomatous polposis and AFAP/Attenuated FAP. Increased risk of CRC 70-100% by 70yr old. LIKELY to develop large number of colorectal adenonas >100 |
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TP53 |
women all cancer risk up to 100% Li-Fraumeni syndrome men all cancer risk up to 73% Elevated risk of all 8 Cancer targets by myrisk as well as rare Adrenocortical carcinomas choroid plexus tumors and sarcoma. Diagnosis in childhood many primary tumors over lifetime. NCN provides detailed guidelines. |
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PTEN |
Syndrome associated Hamartone tumor Subtypes Cowden syndrome Increased risk breast Cancer 25-50% Thyroid 3-10% Endometrial 5-10% CRC up to 7% |
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MUTYH |
MUTYH associated Polyposis(MAP) Recessive (needs biallelic Mutation) increased risk CRC 43-100% Small bowel-increased |
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CDH1 |
Hereditary Diffuse gastric Cancer risk of gastric Cancer 80% |
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CDKN2A |
P16ink4e risk melnoma 76% |
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CDNK2A |
P14ARF/familial Atypical multiple mole Melanoma syndrome (FAMMM) pancreatic cancer 17% |
