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45 Cards in this Set
- Front
- Back
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Volume of distribution
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= amount of drug in body/plasma drug conc
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Drug half life
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= 0.7 x Vd/CL
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How many half lives clear 94% of drug?
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4
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Loading dose
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=Css x Vd
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Maintenance dose
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= Css x Cl
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Phase I metabolism
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redox, hydrolysis yields slightly polar, water soluble metabolites (often still active)
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Phase II metabolism
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acetylation, glucuronidation, sulfation yields very polar inactive metabolites
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higher potency
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lower Km
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higher efficacy
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higher Vmax
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competative antagonist
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higher Km
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irreversible antagonist
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lower Vmax
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partial agonist
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lower maximal efficacy, potency independent
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TI
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= TD50/ED50
=median toxic dose/median effective dose higher is safer |
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glitazones
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increase target cell response to insulin
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bendazole
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antiparasitic
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dipine
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dihydropyridine Ca channel blocker
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prost
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PG analog
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sartan
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AT II antag
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dronate
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bisphosponate
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chol
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musc ag
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stigmine
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anti ACHe
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mustine
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nitrosurea
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curium/chronium
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nondepolarizing NM blockers
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statins
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HMG reductase inhibitors
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afil
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ED
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ane
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inhaled general anesthetic
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azepam
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benzo
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azine
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phenothiazine
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conazole
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antifungal
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barbital
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barbiturate
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caine
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local anesthetic
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cillin
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penicillin
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cycline
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antibiotic, protein synthesis inhibitor
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ipramine
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TCA
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navir
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protease inhibitor
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olol
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b-antag
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operidol
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butyrophenone
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oxin
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cardiac glycoside
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phylline
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methylxanthine
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pril
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ACE inhibitor
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terol
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b2 ag
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tidine
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H2 antag
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triptyline
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TCA
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tropin
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pituitary hormone
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zosin
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a1 antag
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