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45 Cards in this Set

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Volume of distribution
= amount of drug in body/plasma drug conc
Drug half life
= 0.7 x Vd/CL
How many half lives clear 94% of drug?
4
Loading dose
=Css x Vd
Maintenance dose
= Css x Cl
Phase I metabolism
redox, hydrolysis yields slightly polar, water soluble metabolites (often still active)
Phase II metabolism
acetylation, glucuronidation, sulfation yields very polar inactive metabolites
higher potency
lower Km
higher efficacy
higher Vmax
competative antagonist
higher Km
irreversible antagonist
lower Vmax
partial agonist
lower maximal efficacy, potency independent
TI
= TD50/ED50
=median toxic dose/median effective dose
higher is safer
glitazones
increase target cell response to insulin
bendazole
antiparasitic
dipine
dihydropyridine Ca channel blocker
prost
PG analog
sartan
AT II antag
dronate
bisphosponate
chol
musc ag
stigmine
anti ACHe
mustine
nitrosurea
curium/chronium
nondepolarizing NM blockers
statins
HMG reductase inhibitors
afil
ED
ane
inhaled general anesthetic
azepam
benzo
azine
phenothiazine
conazole
antifungal
barbital
barbiturate
caine
local anesthetic
cillin
penicillin
cycline
antibiotic, protein synthesis inhibitor
ipramine
TCA
navir
protease inhibitor
olol
b-antag
operidol
butyrophenone
oxin
cardiac glycoside
phylline
methylxanthine
pril
ACE inhibitor
terol
b2 ag
tidine
H2 antag
triptyline
TCA
tropin
pituitary hormone
zosin
a1 antag