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11 Cards in this Set
- Front
- Back
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General Anesthesia
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loss of consciousness, analgesia, amnesia, inhibition of relexes, decreased muscle tone
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Meyer-Overton Principle
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anesthetic property proportional to fat:water PC
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GA MOA
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potentiate GABA at GABA-AR; act on channels for other NTs, like glutamate
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Nitrous MOA
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acts at NMDA glutamate receptors
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Response to GA greater in
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the elderly and with hypothermia
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Rate limiting step for anesthesia induction
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establishing tension in the blood
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Large blood:gas PC
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halothane; equilibrates slowly
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Small blood:gas PC
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Nitrous and desfluane; equilibrates quickly
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Recovery from anesthesia
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due to drug exhalation--> fastest for nitrous and slowest for halothane
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Halothane toxicity
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hepatotoxicity
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Other actions of GAs
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analgesia
depress respiration decrease BP and CO impair liver and kidney function malignant hyperthermia |
