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6 Cards in this Set

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pos vs. neg controls of gene expression
both:
-require nucleic acid sequence for the control system(cis-acting element)
-require factor that binds to that sequence (trans-acting element)
POSITIVE:stim expression of gene
NEGATIVE:represses expression
transcription factors and repressor prots
-DNA level gene control
-as cells differentiate they shut off some genes permanently
COVALENT modification of histones(mehtylation) and DNA
-DNA methylation is associated with gene inactivation
-Histone acetylation is assoc. w/ gene activation
-Histone methylation also effects gene act.
transcription factors
-many contain DNA binding domain and seperate activation(or repression) domain
transcription act/rep recruit:
-co-activators which have histone acetylase activity
OR
-co-repressors which have histone deacetylase activity
more control of gene exp at DNA level
1)storing inactive gene in heterochromatin which is very compact
2)in euchromatin, altering the ability of the promoter to recruit RNA PolII
3)info recieved from cyto and outside enviro
alternative splicing w/ gene regulation
-use alt. splicing to prod diff prots in diff cells from same gene.
-diff prots that prevent exon recognition or promote it
-different promotors on same gene can produce diff mRNAs
Post-transcriptional regulation of gene expression
REGULATE:
1)cap binding protein
2)translation, either by pos or neg controls
3) half-life of an mRNA