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284 Cards in this Set

  • Front
  • Back
symptoms of zinc deficiency
alopecia
taste abnormalities
impaired wound healing
Dx
benign boney overgrowth in the palate midline
torus palatinus
complication of torus palatinus
mild trauma may cause ulceration

heals slowly because of deccreased blood supply
MC tumor of the salivary
pleomorphic adenoma
what should be done in all patients with epigastric pain
EKG and serum enzymes
what should be done with a foreign body stuck in the esophagus
remove with endoscope

unless in distal esophagus which we observe for excretion
how should a patient with dysphagia be worked up
barium swallow

EGD

motility study
what is seen on histology of achalasia
hypertrophic inner circular muscles with absent or degenerating ganglionic cells of the myenteric plexus
what is dysphagia
difficulty swallowing
what is odynophagia
pain with swallowing
what is the work up for esophageal squamous cell carcinoma
barium

EGD

PET
most accurate test for achalasia
monometry
best initial test for achalasia
barium swallow
why should endoscopy be done in patients with achalasia
to exclude malignancy
what is cricopharyngeal dysfunction
failure of muscle to relax when swalling
how is cricopharyngeal dysfunction diagnosed
video fluoroscopic swallowing study
in the esophagus, what are the only two pathologies that require biopsy
cancer and barrets
Rx options for achalasia
pneumatic dilation

botulinum toxin injection

surgical sectioning or myotomy
what is a complication of myotomy when treating achalasia
GERD
how long does botulinum toxin injection last when treating achalasia
3-6 months
what is pseudochalasia
neoplasm near GE junction doesnt allow swallowing
what is the best initial test for esophageal cancer
barium
what is the most accurate test for esophageal cancer
endoscopy with biopsy
what is used to detect spread of esophageal cancer
CT and MRI
what is used to determine if esophageal cancer is resectable
PET
Rx for esophageal cancer
surgical resection
chemo and radiation

if unresectable, place a stent
what can precipitate esophegeal spasm
drinking cold fluids
what is the most accurate test for esophageal spasm
manometry
what are the two types of esophageal spasms
DES and nutcracker esophagus
what is seen in manometry is DES
multiple simultaneous contractions of the middle and lower esophagus
what is seen in manometry in nutcracker
repetitive, non peristaltic, high amplitude contractions

LES is normal
a/w corkscrew appearance on barium studies
esophageal spasm
Rx that cause drug induced esophagitis
tetracyclines
aspirin
NSAIDs
bisphosphonates
potassium Cl
quinidine
Rx for esophageal spasm
CCB and nitrates
Triad for PVS
esophageal webs
iron deficiency
glossitis
how is schatzki rings Dx
barium studies
what is another name for schatzki ring
peptic stricture
what can cause a schatzki ring
acid reflux
schatzki rings are a/w
hiatal hernia

and intermittent dysphagia
what is a sliding hiatal hernia
GE junction and stomach are displaced through diaphragm
what is a paraesophageal hiatal hernia
stomach protrudes through diaphragm
Rx for schatzki ring
pneumatic dilation
Rx for PVS
iron replacement
complication of zenker diverticulum
aspiration pneumonia
what causes a zenkers diverticulum
incoordination between UES contraction and pharyngeal contraction

causes herniation of mucosa via pulsion mechanism
Rx for zenker diverticulum
cricopharyngeal myotomy
how is zenkers diverticulum diagnosed
barium
how is scleroderma of the esophagus diagnosed
manometry
Rx for scleroderma of the esophagus
PPIs
how is esophageal perforation confirmed
barium
what is seen on barium of esophageal perforation
contrast leaking out
what is mallory weiss tear
tear in submucosal arteries
how are severe bleeds of mallory weiss Rx
epinephrine or electrocautery
how is mallory weiss Dx
endoscopy
a/w crepitus or snap crackle pop on palpation of the subclavian area
esophageal perforation
MCC of epigastric pain
non ulcer dyspepsia
Dx
epigastric pain a/w tenderness
pancreatitis
Dx
epigastric pain a/w bad taste, cough and hoarse
GERD
Dx
epigastric pain a/w diabetes and bloating
gastroparesis
after cardiac problems have been ruled out for epigastric pain, what should be next
endoscopy
Rx for infantile GERD
beast milk or formula mixed with cereal

usually resolves in a year
how is GERD diagnosed
patient history

if unclear do an endoscopy

if negative, do 24 hour pH monitoring
when is endoscopy indicated
signs of obstruction
weight loss
anemia
heme positive stools
more than 5 years with symptoms
what is pyrosis
heart burn
Dx
endoscopy shows symmetric, circumferential narrowing
stricture
Rx for GERD not responsive to medical therapy
nissen fundoplication
-wrapping of stomach around LES

endocinch
-suture LES to tighten it

local heat or radiation of LES
-scars
how long does it take for barrets esophagus to develop
5 years of reflux
what is barrets esophagus
columnar metaplasia
how is barrets diagnosed
biopsy
Rx for duodenal hematoma
nasogastric suctioning with TPN
-resolves in 1-2 weeks
how is duodenal hematoma Dx
CT with oral contrast
Rx for barrets metaplasia
PPIs

endoscopy every 2-3 years
Rx for barrets low grade dysplasia
PPIs

endoscopy every 6-12 months
Rx for barrets high grade dysplasia
radiofrquency ablation
atrophic gastritis is a/w
pernicious anemia (B12 def)
characteristics of gastritis Type A
fundus
autoimmune
decrease gastric acid
anemia
characteristics of gastritis Type B
antrum
H pylori
increased gastric acid
ulcers and cancer
how is gastritis Dx
endoscopy

and test for H pylori
most accurate test for H pylori
endoscopic biopsy
what H pylori tests are positive only during active infection
breath test

stool antigen
what H pylori tests are positive during active and previous infections infection
serology
when is stress ulcer prophylaxis indicated
mechanical ventilation

burns

head trauma

coagulopath
MCC of PUD
1) H pylori

2) NSAIDs
most accurate test for PUD
endoscopy
Rx for PUD
PPIs

eradicate H pylori
best initial Rx for H pylori
PPI
clarithromycin
amoxicillin
-(PCN allergic may use metronidazole)

If resistant add busmuth
next step in a patient with DU that is not responding to Rx
add sucralfate
what shoudl be done in refractory cases of PUD
check gastrin level for ZES
next step in a patient with GU that is not responding to Rx
endoscopy to exclude cancer
Causes of PUD failured treatment
alcohol
smoking
NSAIDs
what is needed to suspect non ulcer dyspepsia
one or more
-epigastric pain
-post prandial fullness
-early satiety
-abdominal burning, nausea, bloating

(normal endoscopy)
when should a patient with dyspepsia get an endoscopy
over 55 yo

alarm symptoms like
-dysphagia
-weight loss
-anemia
next step in px <45 yo with dyspepsia
PPI

serology for H pylori

endoscopy if symptoms dont resolve
Dx
px with postprandial pain, vomiting and early satiety
gastric outlet syndrome
what is gastric outlet syndrome a/w
malignancy
ulcers
crohns
strictures
caustic agents
Dx
px is rocked back and forth and an abdominal succussion splash is heard
gastric outlet syndrome
can also be diabetic gastroparesis
how is gastric outlet syndrome diagnosed
upper endoscopy
why does ZES cause diarrhea
acid inactivates lipase
characteristics of ZES (gastrinoma)
prominant gastric folds
ulcers in distal duadenum and beyond
larger than 2 cm
recurrent after H pylori eradication
best initial test for ZES
endoscopy
most accurate test for ZES
secretin test
-high gastric levels despite secretin
what is done if secretin test is negative in ZES
Calcium infusion test
what gastrin levels are diagnostic of ZEZ
>1000
what is done if gastrin levels cant diagnose ZES
secretin test
what is done after ZES is diagnosed
exclude metastatic disease with

somatostatin recpetor scintigraphy with endoscopic US
how is ZES Rx
local disease is removed

metastatic disease recieves lifelong PPIs
what are the cancers of MEN1
pancreatic
pituitary
parathyroid
most accurate test for diabetic gastroparesis
nuclear gastric emptying study
Rx for diabetic gastroparesis
erythromycin and metoclopramide
what divides an upper and lower GI bleed
ligament of teitz
what determines of a px has orthostasis
10 point rise in pulse when going from laying down to standing up

or

BP drops 20 points when going from laying down to standing up
when should packed RBC be given to a patient with GI bleed
hemtocrit below 30 if
-CAD
-old

if not hematocrit below 20-25
when should platelets be given to px with GI bleed
if bleeding and below 50,000

if not, not until below 10,000-20,000
Rx to prevent subsequents bleeds from esophageal or gastric varices
propanolol
Rx for esophageal or gastric varices
octreotide
banding
Rx for esophageal or gastric varices that cant be controlled with octreotide or banding
TIPS
what is seen on histology of those with laxative abuse
melanosis coli

pigmented macrophages
what is a/w dark brown discoloration with lymph follicles shining through pale patches
laxative abuse
best initial test for pseudomembranous colitis
stool toxin test
most accurate test for pseudomembranous colitis
PCR
best initial Rx for pseudomembranous colitis
metronidazole
Rx for pseudomembranous colitis that doesnt respond to metro
switch to vancomycin or fidoxomicin
Rx for recurrent episode of pseudomembranous colitis
metro
Dx
px develops malabsorption after a surgery
bacterial overgrowth
most accurate test to Dx bacterial overgrowth
jejunal aspirate with endoscopy
what cant a patient with celiac disease eat
wheat
barley
rye
antibodies a/w celiac disease
anti gliadin
anti endomysium
anti transglutaminase
Rx for tropical sprue
folic acid and tetracyclines
Rx for dermatitis herpetiform in celiace disease
dapsone
best initial Dx test for celiace disease
anti transglutaminase Ab
most accurate Dx test for celiace disease
small bowel biopsy
what is seen on biopsy of celiac disease
flattening of villi
most accurate test for whipples disease
small bowel biopsy
most accurate test for tropical sprue
small bowel biopsy
Rx for whipples
ceftriaxone
or
TMP-SMX
what is seen on biopsy of whipples
PAS +, non acid fast macrophage inclusions

(foamy macrphages)
why must biopsy be done in celiac disease
to exclude lymphoma
Dx test for malabsorption secondary to pancreatic insufficiency
stool elastase
most accurate test for chronic pancreatitis
secretin stimulation test
best initial Dx test for chronic pancreatitis
imaging
-x ray
-ERCP
-CT/MRI
next step in a px with pancreatitis that CT shows air in the stomach
NG tube

(ileus causing GI stasis)
Dx
px has liver abscess with pleuritic pain to the should
aspirate is sterile
E histolytica
Rx for E histolytica
metro
Dx
px with necrotic migratory erythema
gucagonoma skin rash
Rx for insulinoma
diazoxide
octreotide
triad for glucoganoma
hyperglycemia
weight loss
dermatitis
best initial test for glucagonoma
fasting glucose and glucogon levels
most accurate test for glucagonoma
CT
when should drainage of pancreatic pseudocyst be done
>6 weeks
>5 cm in diameter
infected
signs associated with hemorrhagic pancreatitis
grey turner
-bluish color on flanks

cullen
-bluish color in periumbilicus
drugs that cause drug indiced pancreatitis
furosemide and thiazides
sulfa, tetracyclines, metro
azathioprine
valproate
didanosine
pentamidine
what is a pancreatic pseudocyst lined by
granulation tissue

lack epithelial lining and are walled by fibrous capsule
best initial Dx test for carcinoid
urinary 5HIAA test
first line Rx for carcinoid
surgical removal
Rx for carcinoid that cant be removed
octreotide
what intestinal pathologies are not a/w weight loss
irritable bowel syndrome
lactose intolerance
how is lactose intolerance confirmed
hydrogen breath test
what symptoms can suggest IBS
improvement after obstaining from lactose

acidic stool pH

presence of positive reducing sugars
Dx
associated with passage of mucous (no blood or WBC) and a sense of incomplete emptying or bloating
IBS
Rx for constipation IBS
lubiprostone
Rx for diarrhea IBS
loperamide
Rx for IBS
fiber

antispasmotics
-hyoscyamine
-dicyclomine

TCA
symptoms suggestive of IBD
diarrhea
weight loss
fever
blood in stool
what can be used as an indication of disease activity in UC
erythema nodosum
Dx
px with UC develops increase alk phosph level
sclerosing cholangitis
when is a px with UC at increased risk for cancer
developing sclerosing cholangitis
when should colonoscopoes be started in px with IBD
after 8-10 year

done every 1-2 years
IBD a/w ASCA
CD
IBD a/w ANCA
UC
Dx
px with IBD shows colonic dilation >6 cm on radiology
toxic megacolon
criteria for toxic megacolon Dx
fever
HR >120
netrophil >10,500
anemia
what happens as UC progresses
rectum loses elasticity and lumen collapses

this leads to tenesmus
most accurate Dx test fro IBD
endoscopy when disease can be reached

if cant be reached perform barium

if still unclear perform serology
Rx for acute exacerbation of IBD
steroids
Rx for chronic maintenance of remission in IBD
mesalamine
what is used to wean px off steroids in IBD
azathioprine and 6MP
Rx for perianal CD
ciprofloxacin and metro
Rx for CD a/w fistula
anti TNF agents

if not surgery
Rx for IBD not responsive to initial therapy
anti TNF agents
MCC of GI bleed in elderly
diverticulosis
most accurate test for diverticulosis
colonoscopy
where at diverticuli most commonly found
sigmoid
best initial test for diverticulitis
CT scan
Rx for abscess a/w diverticulitis
<3 cm = antibiotics

>3cm = CT guided drainage
-if symptoms remain after 5 days, drain and debride
Rx to decrease progressions and complications of diverticulosis
bran
psyllium
methylcellulose
fiber
when is surgery the answer for diverticulitis
no response to medical therapy
frequently recurrent infections
perforation, fistula, abscess, stricture, obstruction
what are the watershed areas of the colon
splenic flexure
rectosigmoid junction
when should colon cancer screening be started
at the age of 50 done every 10 years
when should colonoscopy be started in a px with HNPCC
at the age of 25 done every 1-2 years
when should colonoscopys be done to an individual whos family member got colon cancer at 50
10 prior to their diagnosis done every 5 years
what is the genetic abnormality in FAP
APC gene
when should colonoscopy be started in a px with FAP
at the age of 12 done every year
Dx
colonoscopy shows thousands of polyps
FAP
characteristics of a high risk polyp
villous
sessile
>2.5 cm
which polyps are benign and do not require workup
hyperplastic polyps
when should colonoscopy be done in a patient with single adenomatous polyp
every 3-5 years
when should colonoscopy be done in a patient with previous colon cancer
1 year after resection
then 3 years
then 5 years
what are the findings in multiple hemartoma syndrome
GI hamartomas
Breast cancer
thyroid cancer
nodular gingival hyperplasia
what cancers is peutz jeghers a/w
breast
gonadal
pancreatic
cancers a/w gardners
colon
osteomas
desmoid
cancers a/w turcot
colon
medulloblastoma/glioma
what is cronkhite canada syndrome
juvenile polyps with
-alopecia
-hyperpigmentation
-nail loss (onycholysis)
which colon pathologies do not require increased frequency of colon cancer screening
peutz jeghers
gardner
turcot
juvenile polyposis
symptoms of VIPoma
diarrhea
hypokalemia (leg cramps)
decreased stomach acid
Dx
px with epigastric pain that goes straight to the back "like a spear"
pancreatitis
what is a/w the worst prognosis in pancreatitis
low calcium
best initial test in pancreatitis
amylase and lipase
most specific test for pancreatitis
CT
what correlates to the severity of pancreatitis
degree of necrosis of CT
what is considered extensive necrosis in pancreatitis
>30%
what needs to be done in pancreatitis with extensive necrosis
needle biopsy

and start imipenum
what is ERCP used for in pancreatitis
determine etiology
remove obstructing stone
place a stent
what should be suspected in a px with increased alk phosph and normal GGT
bone pathology
what should be done if GB is calcified on imaging
biopsy (suspect cancer)
MCC of liver function abnormality
acetomenophen
Dx
rapid massive increase in transaminase and only a modest increase in bilirubin and alk phosph
ischemic hepatic injury (shock liver)
what should all patients with chronic liver disease be immunized for
hep A and B
Rx for ascites
Na and water restriction
spironolactone
loops
frequent paracentesis
pathologies a/w SAAG <1.1
infection (except spontaneous peritonitis)
cancer
nephrotic syndrome
pathologies a/w SAAW >1.1
portal HTN
CHF
hepatic vein thrombosis
constrictive pericarditis
what is spontaneous bacterial peritonitis
infection without perforation
best initial test for spontaneous peritonitis
paracentesis that shows >250 neutrophils
most accurate test for spontaneous peritonitis
fluid culture
Rx for spontaneous peritonitis
ceftriaxone
risk factors for GB carcinoma
chronic GB inflammation
history of gallstones
salmonella typhi carrier
Dx
calcium laden GB with bluish color and brittle consistency
GB carcinoma
Rx for hepatorenal syndrome
somatostatin (octreotide)

midodrine
Dx
px develops hypoxia upon sitting upright
hepatopulmonary syndrome
most accurate test for alcoholic liver disease
liver biopsy
symptoms of budd chiari
occlusion of IVC
-ascites
-hepatomegaly
-jaundice
work up for HCC
AFP

then imaging

then biopsy
Dx
benign tumor seen in a young girl on OCP
hepatic adenoma
what teratogens are a/w hepatic angiosarcoma
vinyl chloride
arsenic
thorium
Rx for e granulosa liver cyst
resection and albendazole
Dx
liver cyst that shows egg shell calcification on CT
hydatid cyst (e granulosa)
what is acute acalculous cholecystitis
inflammation of GB without gallstone
how is acalculous cholecystitis Dx
US

CT and HIDA are better
what may cause acalculous cholecystitis
burns
trauma
prolonged TPN or fasting
mechanical ventilation
what is the most accurate test for primary biliary cirrhosis
liver biopsy
Dx
40 yo female with itchin, jaundice, elevated alk phosph and xanthomas
primary biliary cirrhosis
most accurate blood test for primary biliary cirrhosis
antimitochondrial Ab
Rx for primary biliary cirrhosis
ursodeoxycholic acid
MTX
colchicine
auto Ab a/w primary sclerosing cholangitis
pANCA
Dx
px with IBD who develops pruritis, elevated alk phosph and GGT and bilirubin
primary sclerosing cholangitis
most accurate test for primary sclerosing cholangitis
ERCP
what is seen on ERCP in primary sclerosing cholangitis
"pearls on a string"

beading of biliary system
Rx for primary sclerosing cholangitis
cholestyramine

ursodeoxycholic acid
what is seen on histology in A1AT def
hepatocytes that stain with PAS and are resistant to diastase
how is A1AT def Dx
measure serum enzyme level

followed by genetic tests
where is iron absorbed
duodenum
most serious complication of hemochromatosis
HCC
what is seen in joints of px with hemochromatosis
squared off bone ends

osteophytes that look like hooks
what organisms are known to feed off iron
vibrio
yersinia
listeria
best initial test for hemochromatosis
iron studies
what is seen in iron studies in hemochromatosis
increased iron and ferritin

decreased TIBC
most accurate test for hemochromatosis
liver biopsy
what should be done before liver biopsy in hemochromatosis px
MRI and genetic tests
best Rx for hemochromatosis
phlebotomy
when are iron chelating agents used in hemochromatosis
cannot manage with phlebotomy

anemic and have hemochromatosis from overtransfussion (such as thalassemia)
when is hep E most damaging in pregnancy
third trimester
before what years should patients on blood transfusion be screens for hepatitis
1986
what is seen in acute viral hepatitis
bridging fibrosis
what should be done if a mother is detected to have HCV in colostrum
nothing, cant transmit this way
what happens with superinfection with Hep D
increased transaminase levels
best way to determine viral activity in viral hepatitis
PCR
Rx for hep B
antiviral
Rx for hep C
IFN
ribavirin
PI
SE of IFN
arthralgia
thrombocytopenia
depression
leukopenia
SE of ribavirin
anemia
SE of adefovir
renal disfunction
SE of bocepevir
anemia
SE of telaprevir
Rash
another name for wilsons
hepatolenticular degeneration
what is wilsons a/w
fanconis
hemolytic anemia
neuropathy
best initial test for wilsons
slit lamp test
most accurate test fro wilsons
increased urine copper after penicillamine
Rx for wilsons
B6
zinc
trientine
penicillamine
best initial test for autoimmune hepatitis
ANA
LKM Ab
smooth muscle Ab
most accurate test for autoimmune hepatitis
liver biopsy
Rx for autoimmune hepatitis
prednisone
azathioprine
what is seen on biopsy of nonalcoholic steatohepatitis
microvascular fatty deposits
most accurate test for nonalcoholic steatohepatitis
biopsy
nonalcoholic steatohepatitis is a/w
obesity
DM
hyperlipidemia
steroid use
Rx for nonalcoholic steatohepatitis
Rx underlying cause

ursodeoxycholic acid