Ganglionic And Skeletal Muscle Blockers

Front 1

What causes Excitatory Postsnyaptic Potential (EPSP)?

Back 1

Activation of Nn receptor

Front 2

What causes Inhibitory Postsynaptic Potential (IPSP)?

Back 2

Activation of M2 receptor and dopamine release

Front 3

What causes slow exictatory postsynaptic potential (slow EPSP)?

Back 3

Activation of M1 receptor

Front 4

What causes Late slow exitatory postsynaptic potential ( late slow EPSP)?

Back 4

The action of peptide cotransmittors (to Ach) on receptors.

Front 5

What is the predominate tone in blood vessels and what happens when given a ganglionic blocker?

Back 5

Tone: Adernergic
Effects: Dilation and decreased Cardiac Output

Front 6

What is the predominate tone in Heart and what happens when given a ganglionic blocker?

Back 6

Tone: Cholinergic/ Adernergic
Effects: Tachycardia/ Bradycardia

Front 7

What is the predominate tone in GI tract and what happens when given a ganglionic blocker?

Back 7

Tone: Cholinergic
Effects: decreased motility, tone, constipation

Front 8

What is the predominate tone in Bladder and what happens when given a ganglionic blocker?

Back 8

Tone: Cholinergic
Effects: Urinary retention

Front 9

What is the predominate tone in Iris and what happens when given a ganglionic blocker?

Back 9

Tone: Cholinergic
Effects: Mydriasis

Front 10

What is the predominate tone in Cilliary Muscle and what happens when given a ganglionic blocker?

Back 10

Tone: Cholinergic
Effects: Cycloplegia

Front 11

What is the predominate tone in Salivary glands and what happens when given a ganglionic blocker?

Back 11

Tone: Cholinergic
Effects: Dry mouth

Front 12

What is the predominate tone in sweat glands and what happens when given a ganglionic blocker?

Back 12

Tone: Cholinergic
Effects: Reduced sweating

Front 13

What is the predominate tone in Genital tract and what happens when given a ganglionic blocker?

Back 13

Tone: Cholinergic/Adnergic
Effects: Decreased stimulation

Front 14

Mecamylamine (Inversine)

Back 14

Ganglionic blocker
Used in: Hypertensive crisis, controlled hypotension in surgery, hyperreflexia in spinal injuries, Tourette's syndrome, and Cocaine, Nicotine withdrawal (CNS SE)

Front 15

What are the two types of neuromuscular blockers?

Back 15

Depolarizing and Competive

Front 16

Succinylcholine (anectin, quelicin, sucostrin)

Back 16

Depolarizing neuromuscular blocker
Agonist
Rapidly metabolized by plasma esterases
Onset 1-1.5 min, duration 5-8min
Briefly activates receptors (Muscle fasciculations, bradycarida, and tachycardia) and then Desensitiezes motor endplate (paralysis)
Uses: surgery, intubations, fractures, electroshock, and convulsive disorders
SE: Histamine release on rapid infusion, potassium release, abnormal enzyme for metabolism, malignant hyperthermia

Front 17

D-tubocurarine (Tubarine)

Back 17

Non-depolarizing antagonist (neuromuscular blocker)
Chondrodendron bark, alkaloid
Does not cross GI or BBB
No anesthetic properties only muscle paralysis
4-6min onset, 80-120 min duration
Progressive paralysis
Used in: surgery, electroconvulsive shock, and muscle spasms

Front 18

Pancuronium (Pavulon)

Back 18

Nueromuscular blocker
Steroid nucleus
No histamine release, medium ganglionic blocking effects
5-10 times more potent than tubocurarine

Front 19

Doxacurium (Neuromax)

Back 19

Neuromuscular blocker
Benzylisoquinolinium derivative
2-3 times more potent than pancuronium, most potent
Low histamine and ganglioin effects