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18 Cards in this Set
- Front
- Back
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GABA synthesis
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glutamate to GABA via glutamic acid decarboxylase
(GAD) B6 is a cofactor |
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Thiosemicarbazide
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inhibits formation of GABA by interacting w/ B6 cofactor
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What is GAD a marker for?
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GABA
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What is VGAT a marker for?
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GABA or glycine
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Tetanus toxin mechanism
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proteolysis of synaptobrevin
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GABA A receptor: function and location
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ionotropic Cl- channel: hyperpolarizes the cell
usually located post-synaptically |
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GABA B receptor: function and location
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metabotropic: decreases cAMP, increases K+ permeability, reduces Ca2+ influx
Usually presynaptic |
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Some known ligand binding sites on GABA receptors
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GABA
glycine Benzodiazepine Barbiturate Picrotoxin neurosteroids: (allopregnanolone) |
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Muscimol
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GABA A agonist (from amanita muscaria mushroom)
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Diazepam binding inhibitor (DBI)
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endogenous protein that is an inverse agonist at BDZ binding sites (produces anxiety)
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GABA A antagonists (1 competitive, 1 non-competitive)
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Competitive: Bicuculline
Non-competitive: Picrotoxin (also pentylenetetrazol, noncompetitive, for producing experimental convulsions) |
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Agonist at GABA B receptors
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Baclofen
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Antagonist at GABA B receptors
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Phacolfen
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Metabolism of GABA (enzyme and transport)
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GABA-T
GAT 1+2 (all over) GAT 3 (astrocytes) |
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Inhibitor of GAT 1
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Tiagabine
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Inhibitor of GABA-T
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Vigabatrin
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Inhibitors of GABA metabolism
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Tiagabine (GAT1 inhibitor)
Vigabatrin (GABA-T inhibitor) |
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Skeletomotor loop:
Primary effects of direct vs indirect DA pathway |
Direct pathway disinhibits thalamus
Indirect pathway inhibits thalamus |
