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20 Cards in this Set
- Front
- Back
- 3rd side (hint)
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What receptors are Gq linked
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H1, a1, V1, M1, M3
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HAVe 1 M&M
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What receptors are Gs linked
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B1, B2, D1, H2, V2
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What receptors are Gi linked
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M2, a2, D2
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MAD 2's
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Gq activate what to form protein kinase C
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DAG
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Gq activate what to increase Ca from sarcoplasmic reticulum?
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IP3
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Gs stimulate what to from cAMP
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Adenylyl cyclase
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Which two G protein act on adenylyl cyclase?
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Gs (stimulate), Gi(inhibit)
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Where are a1 receptors found? What does it do?
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vascular smooth muscle contraction
contraction dilator muscle of eye (mydriasis) Contraction intestinal and bladder spincter |
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Where are a2 receptors found and what does it do?
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Smooth muscle mixed effects and neurotransmitter inhibition & Cardiac muscle relaxation platelet activation
decrease sympathetic outflow, decrease insulin release |
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Where are Beta 1 receptors found and what do they do?
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Heart and kidneys
increased heart rate, increased contractility, increased renin release, increased lipolysis |
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Where are Beta 2 receptors found and what do they do?
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Vasodilation, bronchodilation, increased heart rate
increased contractility increased lipolysis, increase insulin release, decrease uterine tone. |
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M1
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CNS, enteric nervous system
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M2
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Decrease heart rate and contractility of atria
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M3
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increase exocrine gland secretions (e.g. sweat, gastric acid),
increase gut peristalsis, increase bladder contraction, bronchoconstriction, increase pupillary sphincter muscle contraction (miosis), ciliary muscle contraction (accommodation) |
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D1
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Relaxes renal vascular smooth muscle
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D2
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Modulates transmitter release, especially in brain
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H1 Histamine
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Increase nasal and bronchial mucus production, contraction of bronchioles
pruritus pain |
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H2
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Increase gastric acid secretion
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V1
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increase vascular smooth muscle and contraction
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V2
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increase H20 permeability and reabsorption in the collecting tubules of the kidney (V2 is found in the 2 kidneys)
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