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20 Cards in this Set

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  • Back
  • 3rd side (hint)
What receptors are Gq linked
H1, a1, V1, M1, M3
HAVe 1 M&M
What receptors are Gs linked
B1, B2, D1, H2, V2
What receptors are Gi linked
M2, a2, D2
MAD 2's
Gq activate what to form protein kinase C
DAG
Gq activate what to increase Ca from sarcoplasmic reticulum?
IP3
Gs stimulate what to from cAMP
Adenylyl cyclase
Which two G protein act on adenylyl cyclase?
Gs (stimulate), Gi(inhibit)
Where are a1 receptors found? What does it do?
vascular smooth muscle contraction
contraction dilator muscle of eye (mydriasis)
Contraction intestinal and bladder spincter
Where are a2 receptors found and what does it do?
Smooth muscle mixed effects and neurotransmitter inhibition & Cardiac muscle relaxation platelet activation
decrease sympathetic outflow, decrease insulin release
Where are Beta 1 receptors found and what do they do?
Heart and kidneys
increased heart rate, increased contractility, increased renin release, increased lipolysis
Where are Beta 2 receptors found and what do they do?
Vasodilation, bronchodilation, increased heart rate
increased contractility
increased lipolysis,
increase insulin release, decrease uterine tone.
M1
CNS, enteric nervous system
M2
Decrease heart rate and contractility of atria
M3
increase exocrine gland secretions (e.g. sweat, gastric acid),
increase gut peristalsis,
increase bladder contraction,
bronchoconstriction,
increase pupillary sphincter muscle contraction (miosis),
ciliary muscle contraction (accommodation)
D1
Relaxes renal vascular smooth muscle
D2
Modulates transmitter release, especially in brain
H1 Histamine
Increase nasal and bronchial mucus production, contraction of bronchioles
pruritus
pain
H2
Increase gastric acid secretion
V1
increase vascular smooth muscle and contraction
V2
increase H20 permeability and reabsorption in the collecting tubules of the kidney (V2 is found in the 2 kidneys)