Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
4 Cards in this Set
- Front
- Back
|
What is the major adverse effect of Acetaminophen and Aspirin?
|
Acetaminophen: Hepatic necrosis (at large doses) (!)
Aspirin overdose: respiratory alkalosis, metabolic acidosis Aspiring chronic toxicity (3 grams/day): tinnitus, erosive gastritis, bleeding, analgesic nephropathy |
|
|
What are the mechanisms of adverse drug reactions?
|
Drug overdose, predictable reactions based on drug MOA, altered drug metabolism (due to genetic variations in enzyme activity), idiopathic reactions (rare, unpredictable, may be severe)
|
|
|
What is pharmacogenomics?
|
Use of genotyping to predict and prevent adverse drug reactions
|
|
|
What are examples of idiopathic reactions of drugs?
|
Chloramphenicol: aplastic anemia; Statin drugs: rhabdomyolysis
|
