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23 Cards in this Set
- Front
- Back
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moa of amphotericin
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binds ergosterold and pokes holes in membrane leaking K+
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use of amphotericin
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wide spectrum systemic mycoses
no BBB |
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SE of amphotericin
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fever/chills (shake and bake)
nephrotoxic HOTN anemia arrythmia phlebitis from IV |
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given to reduce toxicity of amphotericin
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liposomal amphotericin
hydration to reduce nephrotoxicity |
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MOA of nystatin
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binds ergosterol (like amphotericin)
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use of nystatin
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swish and swallow for oral candidiasis
topical for diaper rash topical for vaginitis |
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MOA of azoles
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inhibits fungal steroid synthesis
blocks lanosterol to ergosterol |
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use of azoles
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systemic mycoses
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azole that can cross BBB
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fluconazole (cryptococcal meningitis)
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used for hypercortisolism
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ketoconazole
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azoles used for topical infections
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clotrimazole and miconazole
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toxicity of azoles
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gynecomastia
liver dysfunction (inhibits p450) fever, chills |
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MOA of flucytosine
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inhibits DNA synthesis by conversion to fluorouracil (competes with uracil)
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use of flucytosine
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systemic fungal infections like candida and cryptococcus IN CONJUNCTION WITH amphotericin
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toxicity of flucytosine
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N/V/D
bone marrow suppression |
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MOA of caspofungin
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inhibits cell wall synthesis
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use of caspofungin
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invasive aspergillosis
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toxicity of caspofungin
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GI
flushing |
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MOA of terbinafine (lamasil)
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inhibits fungal enzyme squalene epoxidase
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use of terbinafine
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dermatophytoses (onychomycosis)
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MOA of griseofulvin
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interferes with microtubule function in dermatophytes and inhibits synthesis of nucleic acids
deposits in keratin containing tissues (nails) |
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uses of griseofulvin
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dermatophytoses of skin and hair
systemic drug for superficial infection |
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toxicity of griseofulvin
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teratogen/carcinogen
confusion HA induces p450, interferes with warfarin metabolism disulfiram |
