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15 Cards in this Set
- Front
- Back
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Canida Albicans |
makes yeast and pseudohyphae/hyphae Gram +KOH Prep |
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Risk Factors for disseminated canidiasis |
Diabetes, broad spec antibiotics, disruption of skin mucous membranes, Nuetropenia, immunosupressive, dialysis, premature and the old. |
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Cryptococcus Neofomans |
polysaccharide capsule, found in bird droppings, affects immunodeficient, causes lung problems, meningitis, and swiss chease brains inimmune competant people can cause granulomas most common lethal fungal infection in aids end up in giant cells |
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Apergillus |
it is found in soil Angioinvasion, a bunch of lung problems esp in cystic fibrosis lab results increase eosinophilia and IGE RX: steroids, and antifungals Acute branching, COnidiophore (Holy water drop) |
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Mucormycosis |
Acute rhino-orbital-cerebral-infections, Angioinvasion, infects immunocomprimised RX: treat underline medical problem, surgical debriment and amphotericin B Branches at 90 degrees and lots of necrosis and hemorrage, causes thrombosis |
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Blastomycosis |
dimorphic fungus, found in southeastern and south-central states along mississippi and ohio rivers. men 20-40. Does broad-based budding Dissemination causes large ulcers not more common in people with AIDS |
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Histoplasmosis |
inhaled form bird droppings, can infect anyone, ohio and mississippi river.'causes lung problems, reticuloendothelial system
goes inside macrophages bunch of little tiny dots |
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Pneumocystis jirovecci |
Pneomina causes the lung to become solid, affects people with aids organisms dont stain in H&E |
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coccidiodomycosis |
Erythema nodusum-rash due to responce of body to fungus. can dissiminate to cause multiple skin leasions spherule containing endospores. california san joaquin valley region. |
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Fluconazole |
Fungistatic, Oral bioavailability 90%, excreted in Urine, penetrates CSF, reduce does with CKD Most active againts: Canida, Cryptococcal and Coccidioidal meningitis, prophylaxis in AIDS patients Adverse eff: increase liver enzyme, reversible alopecia |
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Itraconazole |
Oral bioavail 55%, hepatic metabolism, fecal excretion, low CSF penetartion use: cutaneous blasto, Lymphocuta sporotrichosis, pulmanary histo, nail infections, inavise aspergillosis adverse eff: increase liver enzyme, nausea, diarrhea, hypertension,edema, congestive heart failure. CYPp450 inhibitor |
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Voriconazole |
Oral 86%, empty stomach, hepatic metabolism, renal excretions, csf penetrations use: drug of choice invasive pulmonary aspergillosis. candida esophagtis Adverse eff: liver enzyme, visual disturbance, cutaneaous malignacy cypinhibitor |
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Posaconazole |
Oral 50-60% increase with fat meal. hepatic metabolism, fecal excretion Use: brodest Azole. used in mucor and prophylaxis for stem cell transplants Adverse effects: diarrhea, skin rash CYP inhibitor |
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Ketoconazole |
Topical for dermatophyre infections Adverse infection: liver enzyme, headache, rash, vometing, endocrine effects, decreased libido |
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Echinocandins |
Fungins', MOA- inhibits fungal cell wall synthesis use: kills cadida, stops aspergillus, better that azole for canida. does nothing for cryptococcus IV only, long half life, hepatic metabolism |
