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30 Cards in this Set

  • Front
  • Back

Intoxication


Infection


Toxicoinfection



-Toxin produced by m/os should be ingested


-High numbers of viable cells should be ingested in food material


-Ingest the high numbers cells produce spores (toxin) within the body

Staphylococcous aureus

Heat treatment can kill the bacteria, toxin will remain and we digest them.




G(+)


non-spore


Sources: Skin,nass-phaynx of humans, boils, wounds, pimples,sinus infection, infected wound


Disturbances:nausea,vomiting,abdominal pain,diarrhea, headache


Pathogenic Agent:Heat stable enterotoxin (release out of the cell) 10^6


Foods:Meat, creamfilled,egg,salad,milk products




Enterotoxin :A,B,C,D,E differ in toxicity





Clostridium (SPORE) Botulinum

Neurotoxin


G(+)


spore forming


anaerobe,gas forming


7 types


Disturbance:Double vision,dizziness, blurred vision, cramps, vomiting, difficulty in swallowing, speaking,respiratory problems




Pathogenic Agent: Heat labile neurotoxin (exotoxin) Toxin is produced during growth




Foods: Low acid canned foods ass. with soil ( meat, beans,corn, asparagus)


Home canned foods


Casual Practices:


-Improper thermal processing,


-improper acidifications,


-incomplete cooking




Infant Botulism: They can get the bacteria that cause illness(infection) Their microflora cannot developed up to 1 year


Wound Botulism: Infection


Toxin formation in body

Clostridium (SPORE) perfringens

G(+)


sporulating


aerotolerant


Disturbances:diarrhea, abdominal pain, no fever or vomiting


Pathogenic Agent:


-İngestion of 10^5 -10^6 viable cell.


-Toxin produced during sporulation


-Toxicoinfection: Infection first, toxin produced within the body


-Enterotoxin is released in the gut during sporulation


-Enterotoxin is heat sensitive inactivated at 60 for 10 minutes




Foods:Meat and poultry


Casual Practices:


Poor sanitation


poor personal hygiene


food inadequately cooked







Bacillus cereus

G(+)


spore forming


aerobic


Disturbances:nausea,diaarhea,abdominal pain,vomiting


Pathogenic Agent:


-VERY LARGE AMOUNT OF 10^8


-Heat stable enterotoxin


-toxicoinfection(Viable cells lysed in gut release enterotoxin)




Foods:potatoes,rice (fried or boil), meat,soup


Casual Practices:


-Improper heatin,


-poor sanitation,


-improper refrigeration



Vibrio parahemolyticus

G(-)


non spore


marine bacterium,halophile requires, lovee nacl


common in Japan


raw sea food!!!


Disturbances: violent upper abdominal pain, diarrhea,vomiting,nausea,fever


Pathogenic Agent:Large amount of cells


Foods:Oysters,shrimps,raw fish


Casual Practices: Eating raw food

Vibrio cholera

G(-)


Waterborne disease


serious world wide


Pathogenic Agent:


-High number of cells


-After infection vibrios bind to the intestine wall multiply there enterotoxin cause very severe diarrhea


Development of Path. Agent:


Water supplies contaminated by human feces


Also can be food borned


Prevention: Senitary treatment of water supplies



Listeria Monocytogenes

BIG TROUBLE FOR FOOD INDUSTRY


G(+)


non spore


psychrotrophic . mean grow at 0-4


Mortality: %30


Highly fatal to fetus, newborns,infants,the elderly, the pregnant, immuno compromised people like cancer aıds..




Disturbances: menengitis, septicemia, abortion


Foods: contaminated manure(gübre), fruits, milk products




Casual Practices :


-Poor sanitation personal hygiene,


- infected animals milk,


improper PASTEURİZATİON

Brucella

G(-)


strict aerobe


Zoonish: cattle,goat


cheese made of goat milk


2 main trasmittences:


1)ingestion from raw milk


2)direct contact: infected animal of handling of contaminated meat


Disturbance; Fever,chills,malaria, weakness,weight loss


Prevention:


-age cheese 90-120 days to kill brucella(high salt conc.) (antagonistic effect might occur two things have the opposite effect)


-pasteruzation


-eliminate diseased animals


Three types :of the bacteria that cause brucellosis


– Brucella abortus,


-Brucella melitensis


-Brucella suis

Salmonella

G(-)


anaerobe


Motile


Two species:Enterica and bongori


Foods: Red meat • Poultry • Milk and milk products • Vegetable • Nuts


Severe disease may cause septicemia


Elderly,infant,immunocompromised adulT


Causal Practices:Enough cook,suitable refrigeration, personal sanitation,


Disturbance :Diarrhea,fever,abdominal cramp

Escherichia Coli

G(-)


non-spore


EPEC,ETEC,EIEC,EHEC,DAEC,EAggEC


EIEC,


EIEC :dysentery similar that cause by shigella spp. 10^6


EPEC;


infantile diarrhea 10^6-10^8


ETEC;


-travellers diarrhea 10^8-10^9


-heat stable toxicoenfection (toxin is produced within the body)


EHEC;


Severe bloody diarrhea


10-100 cells can produce diease


HUS in humans


cattle'


kidney damage


Hamburgers



shigella



Non spore


g(-)


mesophile


salt tolerant


Pathogenic Agent: 1) infection 10cfu is enough-shigatoxin


2) shigatoxin: some strains produce toxin




Water born disease


Bacillary dysentery


Prevention:purification of water supply


4 species


flexneri,dysenteria,boydii,sonne



Yersinia enterocolitica



G(-)


psychrotrophs (düşük sıcaklığa dayanıklı)


PİG milk or touch




Casual practices:


-post pasteuzation contamination


-grow at low degree


-improper cooking

Campylobacter jejuni

G(-)


veterinary diseaase


Disturbances:diarrhea,muscle pain,dizziness,headache,fewer


Sources:found in intestinal tract of cattle,sheep,chicken,ducks


detected in MILK


Foods:raw milk,poultry products,eggs,water


10^4-10^8

streptococcus pyogenes



G(+)


streptococcal sour pharangitis


if a red skin accompanies SCARLET FEVER


tonsillitis bademcik iltihabı


airborne is more common than the food borne


Disturbance; sore throat,pain in swallowing,high fever,nausea,vomiting


Foods:milk,ice cream,eggs,potato


they are detected on blood agar



Richettsias

they need a host to grow


degenerative bacteria like viruses (obligate parasites)


constracted by bites from bloodsucking artropods


-caws infected with the richettsias of fever


-Coxiella burnetti are public health concern because of milk. Qfever


resistant to the temperature

hepatitis virus A and E



infection


Foods:shelly fish,oysters,raw milk,potato salad,cold meat




Symptomps:Jaundice,loss of appetite, gastrointestinal disturbances




hepatitis A= ingestion of bok water or bok food=RNA structure

Mycobacterium bovis

G(+)


produce tuberculosis in human and cattle


M.tuberculoses human verem


Boktan ya da memeden süte


PASTEURIZATİON 61.7 enough to kill m.tuberculosis 62.8 to kill coxiella burnetti


UNDEVELOPEDs COUNTRY

Hepatitis B-C-D

Transfusion of contaminated blood, syringes, needles, sexual contacts, mothers to offspring




B-DNA all the other ones RNA

Poliomyelitis

milk was implicated


lemonade&cream filled pastry


AGENT:


-improperly pasteurized milk


-milk contaminated following processing


Symptomps:Fever, vomiting, headache, pain in muscle, Paralysis


İnitially infects intestine then invade the central nerveous system


ÇOCUK FELCİ


poliovirus

RNA containing virus

reverse enzyme synthesize a DNA strand by using viral RNA as a templete


Poliovirus also occur in nose&throat discharges


Vaccines are avaliable

NORWALK like virus infection

ssRNA


passed in the stool of infected people


Foods:raw shellfish oysters,contaminated water, ice, eggs, raw vegetables


Prevention:


WASH HANDS,cook shellfish


Rehydration therapy


CDC estimates FİFTY PERCENT OF all food borne breaks can be caused from NORWALK like viruses


--Highy contagious, 10 viral particles sufficient to infect


--After recovery, 2 weeks they have it


sewage contamination of water should be under control

Rotavirus dsRNA virus

-most common in infants,young children


Symptomps :fever,vomiting, diarrhea, abdominal pain, dehydration, loss of appetite


How do they spread it?


-spread from sick people with diarrhea


-adults who take care of children


-spread by fecal-oral route


-shed in feces


-spread by contaminated food, hands,objects

Protozoan Infections

form cysts


shedding of cysts into feces may contaminate raw fruit, vegetables

1)Giardia lamlia

-vegetative cysts are avaliable


same symptoms


Source: Food handler


Foods:Raspberries, lettuce, raw fruits



2)cryptosporidium parvum

raw fruits vegetables


unpasteurized apple juice


lettuce,tomats, cucumber, carrot


may carry cysts

3)Entamoeba Hystolytica

cyst form, vegetative forms are avaliable


abdominal cramps, blood diarrhea


fecally contaminated foods are the main vehicle



toxoplasma gondii

60 million men women carry it


very few have symptoms because of proper working immune systme


pregnancy can be difficult

pasteurization

62.8 for 30 min


72 for 15 sec: High T short time: beneficial ones can survive


140 for 4 sec: UHT: till have shelf life, heat stable enzymes can cause spoilage

Mycotoxins---Microbial intoxication

Aflatoxin: Aspergillus flavus veee aspergillus parasiticus bunlar mold :D



Artık sıkılbıs!


Foods: cereals, grains, bread, peanut butter, popcorn




Patulin Toxin: Penicillum expansum; apples and apple product


Ocratoxin: Aspergillus species effects on Alzaihmer, coffee, grain, grapes




GOOD ONES


Aspergillus oryzae: soy productin, sake production


Penicillium chrysogenium: metabolize of penicillin


cheese production