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14 Cards in this Set
- Front
- Back
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what kind of Organism is C.botulinum?
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Gram (+ve)
spore forming rod 4 clinical forms: foodborne wound infant adult infectious botulinum |
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what is foodborne botulinum caused by?
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The ingestion of a preformed
toxic neurotoxin grown by the organism in food. illness is thus considered a food intoxication as opposed to an infection |
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C.botulinum E is carried by which animal?
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Sea mammals
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Which types are most common & of most concern to us?
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Type A - western USA(meats & vegetables)
Type B - Europe (also found in eastern US) Type E - Japan, Canada, US(associated with fish products) |
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what are the class of symptoms of C.botulinum?
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1) GI symptoms
2) Neurological Symptoms |
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what are the GI symptoms?
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nausea
vomiting diarrhea |
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The neurological symptoms?
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weakness
constipation dizziness genreal muscle weakness vertigo respiratory paralysis facial weakness pharyngolaryngeal paralysis death |
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what is the Incubation period of Clostridium botulinum?
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2 hours to 14 days
usually 12 - 36 hours. NB. IP for Tpye E is shorter, the earlier the symptoms appear the more serious |
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what is the mode of action of the neurotoxin?
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inhibition of ACH release
from motor neurons in muscles secretory glands( salivary, sweat, tear) |
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what factors are most often contributing tooutbreaks of botulinum?
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1)inadequate time / temperature during cooking
2)Inadequately processed foods |
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outbreaks of botulism in Canada & Japan are usually type E. Why?
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usually associated with seafood
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what 2 two test are often used in the lab as diagnosis for botulism?
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1)mouse lethality
2)mouse neutralization |
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what is the Mouse lethality test?
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determines whether or not we're dealing with botulism or something thats not botulisms. trying to determine whether or not the neurotoxin present is botulism
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what is mouse neutralization test?
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tells you which specific type of botulism occurs in meds. A,B,C
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