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14 Cards in this Set
- Front
- Back
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what causes the secretion of bile salt. which hormone? |
cholecystokinin |
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what is the major simulus of gastrin |
protein containing food and para sympathetic nerves
acids |
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major stimulus for secretin |
HCL is duodenum |
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what are the components of bile salt? |
glycocholic acid and taurocholic acid |
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bile contains? |
waer bile acids electrolytes phospholipids cholesterol bilirubin |
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what are the diseases that cause fat malabsorption? |
pancreatitis, gall bladder or liver disease |
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what is the inhibitor of pncreatic lipase? |
xenical/ oristat |
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lipoproteins |
structural for assembly apo B ligands for cell surface receptors (apo E and B) ensyme cofactors apo C2 for lipoprotein lipase |
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what are the two major lipid transport pathways? |
exogenous chylomicron pathway ndogenous VLDL/LDL pathway |
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chylomicron assembly |
TAG and other lipid comine with apoB in ER to form
entering bloodstream via the lymphatic system
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lipoprotein - wherer found? - highest activity where? - activated by what? - mutation leads to what?
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- endothelial surface - heart and skeletal muscle and adipose tissues - apo C2 - elevated levels of chylomicrons and plasma TAG |
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familial hypercholesterolemia - leads to what? - caused by? - dominant? - LDL how much higher than noraml? - treated with what? |
- commom form leads to premature atherosclerosis - defec in LDL receptor gene - heterosygotes affected - 2-3 times higher - statins |
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what can you find in the FH patient? |
xanthomas |
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coeliac disease is an autoimmue disease |
antibodies that react with an ensyme transglutaminase present in small intestine the inflammation leads to a flattening of the villi lining and disrupts the function of the intestinal mucosa leading to malabsorption of nutrients. |
