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21 Cards in this Set
- Front
- Back
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rate of change is independent of drug concentration is
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zero order kinetics
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what is first order kinetics
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rate of change is directly proportional to drug concentration
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what are two phases of first order
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distribution phase
elimination phase |
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where do you get C in the equation Vd = A/C
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from the tiem "zero" of the equation
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When can you estimate A?
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during the elimination phase
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T or F/ a small Vd tells you that a drug is highly bound ot plasma proteins
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true
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name several things that alter Vd
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uremia, burns
prenancy ascites dehydration CHF ESRD |
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why does uremia increase Vd
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uric acid in the blood kicks the drug off of the albumin so less bound drug
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ke is the
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elimination constant
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what ist he slope of the line =
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ke
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CL =
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ke x Vd
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what in general affects half life
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storage
elimination |
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you want rate of infusionss = (list two equations)
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eliminationss
CL x Css |
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when infused at the same rate, amount in body at plateau is the same for all drugs with the same _____
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half life
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for intermittent doses Dm rate =
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CL x Css x t
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in order to give a drug once daily, what would the therapeutic window look like?
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probably large so that you're not toxic and still therapeutic
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Dmmax -
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Vd/F x (Cup-Clow(
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tmax =
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ln(cup/clow)/ke
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when Dmmax is administered every tmax, Css will be the average between ____ and ____
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cupper
clower |
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how do you calculate a dosing interval smaller than tmax?
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still want same Css
Dm = (Dmmax/tmas)t |
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to correct for bioavail divide ___ by ___
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IV by F
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