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15 Cards in this Set
- Front
- Back
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name three mech of renal excretion
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glomerular filtration
passive tutublar reabsoprtion active tubular secretion |
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how are lipid soluble drugs handled in the kidney
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passive reabsorption
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how do organic acids and bases get into the urine
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active trasnport
ATPbinding cassettes |
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what is normal GFR
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120-130mL/min
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T or F unbound drugs are freely filtered at glomerulus
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True as long as <75kd
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what determines filtration at kidneys
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GFR
binding to large proteins |
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T or F. active transprot is very important for xenobiotics
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FALSE
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what are the most important mech of drug excretion of drugs
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passive reabsorption
active secretion |
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__% of water is reabsorbed
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99%
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renal clearance is a function of
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renal pH
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do organic acids go through the OAT or OCT?
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Anion because negativley charged
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what is the cockcroft gault equation
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creatinin clearence =
(140-age) x weight/ serum creatinine (mg/dl) x 72 |
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what is normal CrCL in males? females?
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97-137 mL/min
88-128 mL/min |
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what is in bile
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water
electorlytes organic molecules bile acids cholesterol phospholipids bilirubin |
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how do drugs overcome minimum weight for active transport into bile
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phase II conjugation
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