Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
16 Cards in this Set
- Front
- Back
|
where are ATP biding cassette trnasporters expressed
|
liver
kidney intestine testes placenta |
|
|
what do ABCB1 (pglycoprotines) have specificity for
|
amphipathic anions
nonconjugated neutral or weakly basic lipophilic subtrates |
|
|
what are ABCC1-3 good for
|
organic anions, glucuronides, sulfates, glutathione adduct. LTC4
|
|
|
what is ABCG2 good for
|
substantial overlap with aBCB1
|
|
|
what protein tends to bind acidic drugs
|
albumin
|
|
|
what protein tneds to bindbasic drugs
|
alpha1 glycoproteins
|
|
|
name four blood barriers
|
blood brain
blood thymus blood testic blood ocular |
|
|
T or F. lipophilic compounds in free form can pass easily through the BBB
|
true!
|
|
|
what are the two blood ocular barriers
|
blood aqueous
blood retinal |
|
|
how do aas cross the placenta
|
active transport
|
|
|
how does glucose cross the placenta
|
facilitatied diffusion
|
|
|
how do most drugs cross the placenta
|
simple diffusion!
|
|
|
T of R plasma portein binding of drugs impedes the passage of drugs across the placenta
|
FALSE does NOT impede
|
|
|
is amniotic membrane impermeable to serum albumin
|
NO it is permeable to albumin
|
|
|
T or F all classes of IgG can cross the placenta readily
|
true
|
|
|
how much CSF does a normal adult produce
|
140mL with production at 500mL
|
